Browse > Article
http://dx.doi.org/10.7314/APJCP.2012.13.2.665

Genetic Polymorphisms of DNA Repair Genes XRCC1 and XRCC3 and Risk of Colorectal Cancer in Chinese Population  

Zhao, Yi (Department of Gastrointestinal Surgery, Affiliated Shengjing Hospital of China Medical University)
Deng, Xin (Department of Gastrointestinal Surgery, Affiliated Shengjing Hospital of China Medical University)
Wang, Zhen (Department of Gastrointestinal Surgery, Affiliated Shengjing Hospital of China Medical University)
Wang, Qiang (Department of Gastrointestinal Surgery, Affiliated Shengjing Hospital of China Medical University)
Liu, Yixia (Department of Hepatobiliary Surgery, the West China Hospital, Sichuan University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.2, 2012 , pp. 665-669 More about this Journal
Abstract
Aim: The distribution of DNA repair gene XRCC1 and XRCC3 genotypes was used to assess the potential influence of genetic polymorphisms on risk of colorectal cancer, and interactions with other factors. Methods: a 1:2 matched case-control study was conducted with 485 cases and 970 controls. XRCC1 and XRCC2 genotype polymorphisms were based upon duplex polymerase-chain-reaction with the confronting-two-pairprimer (PCR-CTPP) method. Results:The XRCC1 399Cln allele polymorphism was found to be associated with an increased colorectal cancer risk, while an non-significant inversely association was noted for XRCC3 241Thr/Thr genotype. We also found that individuals with the XRCC1 399 Gln and XRCC3 241Met alleles had an elevated risk, while XRCC3241Thr/Thr was proctective. Conclusion: This study is the first to provide evidence of importance of XRCC1 and XRCC3 gene polymorphisms for risk of colorectal cancer in the Chinese population.
Keywords
XRCC1; XRCC3; genetic polymorphisms; colorectal cancer; Chinese population;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Basso D, Navaglia F, Fogar P, et al (2007). DNA repair pathways and mitochondrial DNA mutations in gastrointestinal carcinogenesis. Clin Chim Acta, 381, 50-5.   DOI
2 Brenneman MA, Weiss AE, NickoloV JA, et al (2000). XRCC3 is required for eYcient repair of chromosome breaks by homologous recombination. Mutat Res, 459, 89-97.   DOI
3 Caldecott K, Jeggo P (1991). Cross-sensitivity of gammaraysensitive hamster mutants to cross-linking agents. Mutat Res, 255, 111-21.   DOI
4 Chen S, Tang D, Xue K, et al (2002). DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population. Carcinogenesis, 23, 1321-5.   DOI   ScienceOn
5 Doll R, Peto R (1981). The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst, 66, 1191-308.
6 de Jong MM, Nolte IM, te Meerman GJ, et al (2002). Lowpenetrance genes and their involvement in colorectal cancer susceptibility. Cancer Epidemiol Biomarkers Prev, 11, 1332-52.
7 Egger M, Davey SG, Schneider M, et al (1997). Bias in metaanalysis detected by a simple, graphical test. BMJ, 315, 629-34.   DOI
8 Han J, Hankinson SE, Colditz GA, et al (2004). Genetic variation in XRCC1, sun exposure and risk of skin cancer. Br J Cancer, 91, 1604-2609.   DOI
9 Hong YC, Lee KH, Kim WC, et al (2005). Polymorphisms of XRCC1 gene, alcohol consumption and colorectal cancer. Int J Cancer, 116, 428-32.   DOI   ScienceOn
10 Hu JJ, Smith TR, Miller MS, et al (2001). Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity. Carcinogenesis, 22, 917-22.   DOI   ScienceOn
11 Hu JJ, Mohrenweiser HW, Bell DA, et al (2002). Symposium overview: genetic polymorphisms in DNA repair and cancer risk. Toxicol Appl Pharmacol, 185, 64-73.   DOI
12 International Agency for Research on Cancer (2008). Colorectal Cancer Incidence and Mortality Worldwide in 2008. 2011, http://globocan.iarc.fr.
13 Improta G, Sgambato A, Bianchino G, et al (2008). Polymorphisms of the DNA repair genes XRCC1 and XRCC3 and risk of lung and colorectal cancer: a case-control study in a Southern Italian population. Anticancer Res, 28, 2941-6.
14 Kiuru A, Lindholm C, Heinavaara S, et al (2008). XRCC1 and XRCC3 variants and risk of glioma and meningioma. J Neurooncol, 88, 135-42.   DOI
15 Lunn RM, Langlois RG, Hsieh LL, et al (1999). XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency. Cancer Res, 59, 2557-61.
16 Mort R, Mo L, McEwan C, et al (2003). Lack of involvement of nucleotide excision repair gene polymorphisms in colorectal cancer. Br J Cancer, 89, 333-7.   DOI   ScienceOn
17 Pierce AJ, Johnson RD, Thompson LH, et al (1999). XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev, 23, 2633-8.
18 Potter JD (1999). Colorectal cancer: molecules and populations. J Natl Cancer Inst, 91, 916-32.   DOI
19 Smith TR, Miller MS, Lohman K, et al (2003). Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. Cancer Lett, 190, 183-90.   DOI
20 Shen MR, Jones IM, Mohrenweiser H (1998). Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res, 58, 604-8.
21 Stern MC, Siegmund KD, Corral R, et al (2005). XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk. Cancer Epidemiol Biomarkers Prev, 14, 609-15.   DOI
22 Thomas HJ (1993). Familial colorectal cancer. BMJ, 307, 277-8.   DOI
23 Thompson LH, Brookman KW, Jones NJ, et al (1990). Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange. Mol Cell Biol, 10, 6160-71.   DOI
24 Tranah GJ, Giovannucci E, Ma J, et al (2004). XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev, 13, 1090-1.
25 Tudek B (2007). Base excision repair modulation as a risk factor for human cancers. Mol Aspects Med, 28, 258-75.   DOI
26 Whitehouse CJ, Taylor RM, Thistlethwaite A, et al (2001). XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell, 104, 107-17.   DOI
27 Yin G, Morita M, Ohnaka K, et al (2012). Genetic Polymorphisms of XRCC1, Alcohol Consumption, and the Risk of Colorectal Cancer in Japan. J Epidemiol, 22, 64-71.   DOI
28 Yu HP, Zhang XY, Wang XL, et al (2004). DNA repair gene XRCC1 polymorphisms, smoking and esophageal cancer risk. Cancer Detect Prev, 28, 194-9.   DOI
29 Zhou W, Liu G, Miller DP, et al (2003). Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk. Cancer Epidemiol Biomarkers Prev, 12, 359-65.