[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.7314/APJCP.2012.13.1.399

Bufalin, a Traditional Oriental Medicine, Induces Apoptosis in Human Cancer Cells

Takai, Noriyuki (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine)
Kira, Naoko (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine)
Ishii, Terukazu (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine)
Yoshida, Toshie (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine)
Nishida, Masakazu (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine)
Nishida, Yoshihiro (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine)
Nasu, Kaei (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine)
Narahara, Hisashi (Department of Obstetrics and Gynecology, Oita University Faculty of Medicine)

Publication Information

Asian Pacific Journal of Cancer Prevention / v.13, no.1, 2012 , pp. 399-402 More about this Journal

Abstract

Bufalin is a traditional oriental medicines which induces apoptosis in some lines of human tumor cells. It constitutes the major digoxin-like immunoreactive component of Chan Su, obtained from the skin and parotid venom glands of toads. Bufalin is cardioactive C-24 steroids that exhibits a variety of biological activities, such as cardiotonic, anaesthetic, blood pressure stimulatory, respiratory and antineoplastic effects. In terms of its anti-tumor activity, bufalin has been demonstrated to inhibit the growth of tumors, such as endometrial and ovarian cancers. This commentary introduces biologic and therapeutic effects of bufalin in treating some cancers. The compound is able to mediate inhibition of cell growth, cell cycle arrest, apoptosis, and expression of genes related to the malignant phenotype in human cancer cells.

Keywords

Traditional oriental medicines; bufalin; cell cycle; apoptosis; cancer;

Citations & Related Records

Reference

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1	Cytotoxicity, Apoptosis Induction and Anti-Metastatic Potential of Oroxylum indicum in Human Breast Cancer Cells / [Kumar, D.R. Naveen;George, V. Cijo;Suresh, P.K.;Kumar, R. Ashok;] / Asian Pacific Journal of Cancer Prevention
2	Biotoxins for Cancer Therapy / [Liu, Cui-Cui;Yang, Hao;Zhang, Ling-Ling;Zhang, Qian;Chen, Bo;Wang, Yi;] / Asian Pacific Journal of Cancer Prevention