Browse > Article
http://dx.doi.org/10.7314/APJCP.2012.13.1.395

Associations between Adiponectin and Two Different Cancers: Breast and Colon  

Gulcelik, Mehmet Ali (General Surgery, Ankara Oncology Training and Research Hospital, Ministry of Health)
Colakoglu, Kadri (General Surgery, Ankara Oncology Training and Research Hospital, Ministry of Health)
Dincer, Halil (General Surgery, Ankara Oncology Training and Research Hospital, Ministry of Health)
Dogan, Lutfi (General Surgery, Ankara Oncology Training and Research Hospital, Ministry of Health)
Yenidogan, Erdinc (General Surgery, Ankara Oncology Training and Research Hospital, Ministry of Health)
Gulcelik, Nese Ersoz (Department of Endocrinology and Metabolism, Faculty of Medicine, Hacettepe University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.1, 2012 , pp. 395-398 More about this Journal
Abstract
Objectives: Breast and colon cancer are neoplasms well known to be related to obesity. Adiponectin, a protein that increases in obesity, seems to be involved in the relationship but clinical data are limited. Methods: In this study, we therefore evaluated the serum adiponectin levels in 87 breast and 27 colon cancer patients and assessed the relation with BMI, menopausal status, receptor status and stage of disease. Results: Serum adiponectin levels were lower in cancer cases ($8583{\pm}2095$ ng/ml for breast cancer, $9513{\pm}2276$ for colon cancer) than in controls ($13905{\pm}3263$). Conclusion: A low serum adiponectin level may be associated with both breast and colon cancer, and that this association is not statistically significant for either receptor or menopausal status in breast cancer groups.
Keywords
Adiponectin; breast cancer; colon cancer; obesity; adipose tissue; adipocytokines;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Weyer C, Funahashi T, Tanaka S, et al (2001). Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab, 86, 1930-5.   DOI
2 Fukumoto J, Otake T, Tajima O, et al (2008). Adiponectin and colorectal adenomas: Self Defense Forces Health Study. Cancer Sci, 99,781-6.   DOI
3 Goktas S, Yilmaz MI, Caglar K, et al (2005). Prostate cancer and adiponectin. Urology, 65, 1168-72.   DOI
4 Grossmann ME, Nkhata KJ, Mizuno NK, et al (2008). Effects of adiponectin on breast cancer cell growth and signaling. Br J Cancer, 29, 370-9.
5 Hu E, Liang P, Spiegelman BM (1996). AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem, 3, 10697-703.
6 Ishikawa M, Kitayama J, Kazama S, et al (2005). Plasma adiponectin and gastric cancer. Clin Cancer Res, 11, 466-7.
7 Kang JH, Yu BY, Youn DS (2007). Relationship of serum adiponectin and resistin levels with breast cancer risk. J Korean Med Sci, 22, 117-21.   DOI
8 Karaduman M, Bilici A, Ozet A, et al (2007). Tissue levels of adiponectin in breast cancer patients. Med Oncol, 24, 361-6.   DOI
9 Kelesidis I, Kelesidis T, Mantzoros CS (2006). Adiponectin and cancer: a systematic review. Br J Cancer, 94, 1221-5.   DOI
10 Kim AY, Lee YS, Kim KH, et al (2010). Adiponectin represses colon cancer cell proliferation via adipoR1- and -R2- mediated AMPK activation. Mol Endocrinol, 24, 1441-52.   DOI
11 Kumor A, Daniel P, Pietruczuk M, et al (2009). Serum leptin, adiponectin, and resistin concentration in colorectal adenoma and carcinoma (CC) patients. Int J Colorectal Dis, 24, 275-278.   DOI
12 Mantzoros C, Petridou E, Dessypris N, et al (2004). Adiponectin and breast cancer risk. J Clin Endocrinol Metab, 89, 1102-7.   DOI
13 Matsuzawa Y, Funahashi T, Nakamura T (1999). Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte derived bioactive substances. Ann N Y Acad Sci, 892, 146-54.   DOI
14 Arditi JD, Venihaki M, Karalis KP, et al (2007). Antiproliferative effect of adiponectin on MCF7 breast cancer cells: a potential hormonal link between obesity and cancer. Horm Metab Res, 39, 9-13.   DOI
15 Arita Y, Kihara S, Ouchi N, et al (1999). Paradoxical decrease of an adipose specific protein, adiponectin in obesity. Biochem Biophys Res Commun, 257, 79-83.   DOI
16 Brakenhielm E, Veitonmaki N, Cao R, et al (2004). Adiponectininduced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cellapoptosis. Proc Natl Acad Sci USA, 101, 2476-81.   DOI
17 Chandran M, Phillips SA, Ciaraldi T, et al (2003). Adiponectin: more than just another fat cell hormone? Diab Care, 26, 2442-50.   DOI
18 Chen DC, Chung YF, The YT, et al (2006). m Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer Lett, 237, 109-14.   DOI
19 Dal Maso L, Augustin LS, Karalis A, et al (2004). Circulating adiponectin and endometrial cancer risk. J Clin Endocrinol Metab, 89, 1160-3.   DOI
20 Dieudonne MN, Bussiere M, Dos Santos E, et al (2006). Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. Biochem Biophys Res Commun, 345, 271-9.   DOI
21 Fujisawa T, Endo H, Tomimoto A, et al (2008). Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut, 57, 1531-8.   DOI
22 Sugiyama M, Takahashi H, Hosono K, et al (2009). Adiponectin inhibits colorectal cancer cell growth through the AMPK/ mTOR pathway. Int J Oncol, 34, 339-44.
23 Wolk A, Gridley G, Svensson M, et al (2001). A prospective study of obesity and cancer risk (Sweden). Cancer Causes Control, 12, 13-21.   DOI
24 Yamauchi T, Kamon J, Ito Y, et al (2003). Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature, 423, 762-9.   DOI
25 Miyoshi Y, Funahashi T, Kihara S, et al (2003). Association of serum adiponectin levels with breast cancer risk. Clin Cancer Res, 9, 5699-704.
26 Okamoto Y, Kihara S, Ouchi N, et al (2002). Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation, 106, 2767-70.   DOI
27 Otake S, Takeda H, Suzuki Y, et al (2005). Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance. Clin Cancer Res, 11, 3642-6.   DOI
28 Petridou E, Mantzoros C, Dessypris N, et al (2003). Plasma adiponectin concentrations in relation to endometrial cancer: a case-control study in Greece. J Clin Endocrinol Metab, 88, 993-7.   DOI
29 Schlienger JL, Luca F, Vinzio S, et al (2009). Obesity and cancer. Rev Med Interne, 30, 776-82.   DOI
30 Takahata C, Miyoshi Y, Irahara N, et al (2007). Demonstration of Adiponectin Receptors 1 and 2 mRNA expression in human breast cancer cells. Cancer Lett, 250, 229-36.   DOI
31 Tian YF, Chu CH, Wu MH, et al (2007). Anthropometric measures, plasma adiponectin, and breast cancer risk. Endocr Relat Cancer, 14, 669-677.   DOI
32 Tworoger SS, Eliassen AH, Kelesidis T, et al (2007). Plasma adiponectin concentrations and risk of incident breast cancer. J Clin Endocrinol Metab, 92, 1510-6.   DOI
33 Wei EK, Giovannucci E, Fuchs CS, et al (2005). Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst, 97, 1688-94.   DOI