Browse > Article
http://dx.doi.org/10.7314/APJCP.2012.13.1.325

Lack of Association Between GSTM1 and GSTT1 Polymorphisms and Brain Tumour Risk  

Sima, Xiu-Tian (Department of Neurosurgery, West China Hospital of Sichuan University)
Zhong, Wei-Ying (Department of Neurosurgery, West China Hospital of Sichuan University)
Liu, Jian-Gang (Department of Neurosurgery, Shenzhen Children Hospital)
You, Chao (Department of Neurosurgery, West China Hospital of Sichuan University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.1, 2012 , pp. 325-328 More about this Journal
Abstract
Objective: Glutathione S-transferases (GSTs) are important enzymes that are involved in detoxification of environmental carcinogens. Molecular epidemiological studies have been conducted to investigate the association between GSTM1 and GSTT1 homozygous deletion polymorphisms and brain tumours but results have been conflicting. The aim of this study was to clarify this problem using a meta-analysis. Methods: A total of 9 records were identified by searching the PubMed and Embase databases. Fixed- and random-effects models were performed to estimate the pooled odds ratios. Results: No significant association was found between the GSTM1 and GSTT1 homozygous deletion polymorphisms and risk of brain tumours, including glioma and meningioma. Similar negative results were also observed in both population-based and hospital-based studies. Conclusion: These findings indicate that the GSTM1 and GSTT1 polymorphisms may not be related to the development of brain tumours.
Keywords
GSTM1; GSTT1; polymorphism; brain tumours; meta-analysis;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Lai R, Crevier L, Thabane L (2005). Genetic polymorphisms of glutathione S-transferases and the risk of adult brain tumors: a meta-analysis. Cancer Epidemiol Biomarkers Prev, 14, 1784-90.   DOI
2 Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
3 Norppa H (2004). Cytogenetic biomarkers and genetic polymorphisms. Toxicol Lett, 149, 309-34.   DOI
4 Pinarbasi H, Silig Y, Gurelik M (2005). Genetic polymorphisms of GSTs and their association with primary brain tumor incidence. Cancer Genet Cytogenet, 156, 144-9.   DOI
5 Schwartzbaum JA, Ahlbom A, Lonn S, et al (2007). An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. Cancer Epidemiol Biomarkers Prev, 16, 559-65.   DOI
6 Trizna Z, De Andrade M, Kyritsis AP, et al (1998). Genetic polymorphisms in glutathione S-transferase (mu) and (theta), N- acetyltransferase, and CYP1A1 and risk of gliomas. Cancer Epidemiology Biomarkers and Prevention, 7, 553-5.
7 Wrensch M, Kelsey KT, Liu M, et al (2004). Glutathione-Stransferase variants and adult glioma. Cancer Epidemiol Biomarkers Prev, 13, 461-7.
8 De Roos AJ, Rothman N, Inskip PD, et al (2003). Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev, 12, 14-22.
9 DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88.   DOI
10 Elexpuru-Camiruaga J, Buxton N, Kandula V, et al (1995). Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci. Cancer Res, 55, 4237-9.
11 Ezer R, Alonso M, Pereira E, et al (2002). Identification of glutathione S-transferase (GST) polymorphisms in brain tumors and association with susceptibility to pediatric astrocytomas. J Neurooncol, 59, 123-34.   DOI
12 Fisher JL, Schwartzbaum JA, Wrensch M, et al (2007). Epidemiology of brain tumors. Neurol Clin, 25, 867-90.   DOI
13 Hayes JD, Pulford DJ (1995). The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol, 30, 445-600.   DOI
14 Hayes JD, Strange RC (2000). Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology, 61, 154-66.   DOI
15 Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58.   DOI
16 Inskip PD, Linet MS, Heineman EF (1995). Etiology of brain tumors in adults. Epidemiol Rev, 17, 382-414.   DOI
17 Jemal A, Siegel R, Xu J, et al (2010). Cancer statistics, 2010. CA Cancer J Clin, 60, 277-300.   DOI
18 Kondratieva TV, Imyanitov EN, Togo AV, et al (2000). L-MYC and GSTM1 polymorphisms are associated with unfavourable clinical parameters of gliomas. J Exp Clin Cancer Res, 19, 197-200.
19 Coles BF, Kadlubar FF (2003). Detoxification of electrophilic compounds by glutathione S-transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs? Biofactors, 17, 115-30.   DOI
20 Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101.   DOI
21 Custodio AC, Almeida LO, Pinto GR, et al (2010). GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas. Genet Mol Res, 9, 2328-34.   DOI