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http://dx.doi.org/10.7314/APJCP.2012.13.1.315

Cyclooxygenase-2 Expression is not a Marker of Poor Survival in Lung Cancer  

Turk, H. Mehmet (Department of Medical Oncology, Faculty of Medicine, Gaziantep University)
Camci, Celalettin (Department of Medical Oncology, Faculty of Medicine, Gaziantep University)
Sevinc, Alper (Department of Medical Oncology, Faculty of Medicine, Gaziantep University)
Bukyukberber, Suleyman (Gazi University, Faculty of Medicine, Department of Medical Oncology)
Sari, Ibrahim (Department of Pathology, Faculty of Medicine, Gaziantep University)
Adli, Mustafa (Department of Radiation Oncology, Faculty of Medicine, Gaziantep University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.1, 2012 , pp. 315-318 More about this Journal
Abstract
Objective: Cyclooxygenase-2 (COX-2) has been claimed to play role in carcinogenesis and be related to a bad prognosis in tumours. The aim of this study was to investigate the relationship between COX-2 expression and clinical and pathological parameters in early and advanced stage lung cancer patients. Materials and Methods: A total of 73 patients with lung cancer (27 adenocarcinomas, 33 squamous cell carcinomas, 4 large cell carcinomas and 9 small cell cancer) were analysed retrospectively. COX-2 expression was evaluated by immunohistochemistry in resection materials or lung biopsies. Tumor cells demonstrating more intense staining than smooth muscle and endothelial cells were recorded as COX-2 positive. We investigated the correlation between increased COX-2 expression and histological type of the tumor, the stage of the disease and survival. Results: COX-2 expression was observed in 55% of the adenocarcinomas, 45% of the squamous cell carcinomas and 22% of the small cell carcinomas. No correlation was apparent between COX-2 expression and disease stage, histological type and the survival. Conclusion: The results of this study do not support COX-2 expression as an independent prognostic factor in lung cancer. However, since results of the literature are different, further studies made in larger series are needed.
Keywords
Cyclooxygenase 2; COX 2; immunohistochemistry; lung cancer; Turkey;
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