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http://dx.doi.org/10.7314/APJCP.2012.13.1.191

Evaluation of DNA Repair Gene XRCC1 Polymorphism in Prediction and Prognosis of Hepatocellular Carcinoma Risk  

Li, Qiu-Wen (Oncology Department, No 1 Hospital Affiliated to the General Hospital of the Chinese People's Liberation Army)
Lu, Can-Rong (General Hospital of the Chinese People's Liberation Army)
Ye, Ming (Oncology Department, No 1 Hospital Affiliated to the General Hospital of the Chinese People's Liberation Army)
Xiao, Wen-Hua (Oncology Department, No 1 Hospital Affiliated to the General Hospital of the Chinese People's Liberation Army)
Liang, Jun (Department of Oncology, the Affiliated Hospital, Medical College of Qingdao University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.1, 2012 , pp. 191-194 More about this Journal
Abstract
We conducted a case-control study in China to clarify the association between XRCC1-Arg399Gln polymorphism and HCC risk. A total of 150 cases and 158 controls were selected from the the Affiliated Hospital of Qingdao University from May 2008 to May 2010. XRCC1-Arg399Gln polymorphism was based upon duplex polymerase-chain-reaction with the confronting-two-pairprimer (PCR-CTPP) method. All analyses were performed using the STATA statistical package. A significantly increased risk was associated with the Arg/Gln genotype (adjusted OR 1.78, 95%CI=1.13-2.79) compared with genotype Arg/Arg. In contrast, the Gln/Gln genotype had non-significant increased risk of HCC with adjusted OR (95%CI) of 1.69 (0.93-2.66). A significant association was found between positive HBsAg and Arg/Gln, with an OR of 3.43 (95% CI=1.45-8.13). Patients carrying Gln/Gln genotypes showed significantly lower median survival than Arg/Arg genotypes (HR=1.38, 95% CI=1.04-1.84). Further Kaplan-Meier analysis showed decreased median survival in Arg/Gln+Gln/Gln genotype carriers in comparison to Arg/Arg carriers (HR=1.33, 95% CI=1.02-1.76). In conclusion, we observed that XRCC1-Arg399Cln polymorphism is associated with susceptibility to HCC, and XRCC1 Gln allele genotype showed significant prognostic associations.
Keywords
Polymorphism; XRCC1-Arg399Cln; hepatocellular carcinoma risk; prognosis; China;
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