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http://dx.doi.org/10.7314/APJCP.2012.13.12.6005

Identification of Genetic and Non-genetic Risk Factors for Nasopharyngeal Carcinoma in a Southeast Asian Population  

Hashim, Nikman Adli Nor (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City)
Ramzi, Nurul Hanis (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City)
Velapasamy, Sharmila (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City)
Alex, Livy (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City)
Chahil, Jagdish Kaur (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City)
Lye, Say Hean (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City)
Munretnam, Khamsigan (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City)
Haron, Mohd Roslan (Department of Radiotherapy and Oncology, Hospital Sultan Ismail)
Ler, Lian Wee (Molecular Research and Services Laboratory, INFOVALLEY(R) Life Sciences Sdn. Mines Resort City)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.12, 2012 , pp. 6005-6010 More about this Journal
Abstract
Background: Nasopharyngeal carcinoma (NPC) is endemic in Southern Chinese and Southeast Asian populations. Geographical and ethnic clustering of the cancer is due to genetic, environmental, and lifestyle risk factors. This case-control study aimed to identify or confirm both genetic and non-genetic risk factors for NPC in one of the endemic countries, Malaysia. Materials and Methods: A panel of 768 single-nucleotide polymorphisms (SNPs) previously associated with various cancers and known non-genetic risk factors for NPC were selected and analyzed for their associations with NPC in a case-control study. Results: Statistical analysis identified 40 SNPs associated with NPC risk in our population, including 5 documented previously by genome-wide association studies (GWAS) and other case-control studies; the associations of the remaining 35 SNPs with NPC were novel. In addition, consistent with previous studies, exposure to occupational hazards, overconsumption of salt-cured foods, red meat, as well as low intake of fruits and vegetables were also associated with NPC risk. Conclusions: In short, this study confirmed and/or identified genetic, environmental and dietary risk factors associated with NPC susceptibility in a Southeast Asian population.
Keywords
SNP; nasopharyngeal carcinoma; association study; cancer risk; Southeast Asia;
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