Browse > Article
http://dx.doi.org/10.7314/APJCP.2012.13.12.5981

MMP1 rs1799750 Single Nucleotide Polymorphism and Lung Cancer Risk: A Meta-analysis  

Hu, Jiang (Department of Oncology, Taihe Hospital Affiliated with Hubei University of Medicine)
Pan, Jun (Department of Oncology, Taihe Hospital Affiliated with Hubei University of Medicine)
Luo, Zhi-Guo (Department of Oncology, Taihe Hospital Affiliated with Hubei University of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.12, 2012 , pp. 5981-5984 More about this Journal
Abstract
Background: Numerous studies have investigated the association of matrix metalloproteinase 1 (MMP1) rs1799750 single nucleotide polymorphism with lung cancer susceptibility, but the findings are inconsistent. Therefore, we performed a meta-analysis to comprehensively evaluate any possible association. Methods: We searched publications from MEDLINE, EMBASE and CNKI databases which assessed links between the MMP1 rs1799750 polymorphism and lung cancer risk. We calculated the pooled odds ratio (OR) and its 95% confidence interval (95%CI) using either fixed-effects or random-effects models. Results: The meta-analysis was based on 9 publications encompassing 4,823 cases and 4,298 controls. The overall results suggested there was a significant association between the MMP1 rs1799750 polymorphism and lung cancer risk (1G vs. 2G: OR = 0.83, 95%CI = 0.73-0.94; 1G1G vs. 2G2G: OR = 0.73, 95%CI = 0.59-0.92; 1G1G vs. 1G2G/2G2G: OR = 0.87, 95%CI = 0.79-0.97; 1G1G/1G2G vs. 2G2G: OR = 0.78, 95%CI = 0.64-0.95). In the subgroup analysis by ethnicity, the association was still obvious in Asians (all P values < 0.05), but there was no association in Caucasians (all P values > 0.05). Conclusions: The MMP1 rs1799750 polymorphism is associated with decreased lung cancer risk, and a race-specific effect may exist in this association.
Keywords
MMP1; lung cancer; single nucleotide polymorphism; meta; analysis; ethnic groups;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Zhang WQ, Lin H, Zhou YA, et al (2006). [Association of MMP1 -1607(1G>2G) single nucleotide polymorphism with susceptibility to lung cancer in Northwestern Chinese population of Han nationality]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 23, 313-5.
2 Zhou J, Brinckerhoff C, Lubert S, et al (2011). Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors. Cancer Invest, 29, 599-607.   DOI   ScienceOn
3 Zhou Y, Yu C, Miao X, et al (2005). Functional haplotypes in the promoter of matrix metalloproteinase-2 and lung cancer susceptibility. Carcinogenesis, 26, 1117-21.   DOI   ScienceOn
4 Zhu Y, Spitz MR, Lei L, et al (2001). A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility. Cancer Res, 61, 7825-9.
5 Gonzalez-Arriaga P, Lopez-Cima MF, Fernandez-Somoano A, et al (2008). Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk. BMC Cancer, 8, 378.   DOI
6 Hart K, Landvik NE, Lind H, et al (2011). A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer. Lung Cancer, 71, 123-9.   DOI   ScienceOn
7 Herbst RS, Heymach JV, Lippman SM (2008). Lung cancer. N Engl J Med, 359, 1367-80.   DOI   ScienceOn
8 Higgins JP, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60.   DOI   ScienceOn
9 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90.   DOI
10 Kimman M, Norman R, Jan S, et al (2012). The Burden of Cancer in Member Countries of the Association of Southeast Asian Nations (ASEAN). Asian Pac J Cancer Prev, 13, 411-20.   DOI
11 Liu D, Duan W, Guo H, et al (2011). Meta-analysis of associations between polymorphisms in the promoter regions of matrix metalloproteinases and the risk of colorectal cancer. Int J Colorectal Dis, 26, 1099-105.   DOI   ScienceOn
12 Liu D, Guo H, Li Y, et al (2012). Association between polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and risk of cancer metastasis: a meta-analysis. PLoS One, 7, e31251.   DOI
13 Liu L, Wu J, Wu C, et al (2011). A functional polymorphism (-1607 1G-->2G) in the matrix metalloproteinase-1 promoter is associated with development and progression of lung cancer. Cancer, 117, 5172-81.   DOI   ScienceOn
14 Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
15 Nelson AR, Fingleton B, Rothenberg ML, et al (2000). Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol, 18, 1135-49.
16 Peng B, Cao L, Wang W, et al (2010). Polymorphisms in the promoter regions of matrix metalloproteinases 1 and 3 and cancer risk: a meta-analysis of 50 case-control studies. Mutagenesis, 25, 41-8.   DOI   ScienceOn
17 Sauter W, Rosenberger A, Beckmann L, et al (2008). Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer. Cancer Epidemiol Biomarkers Prev, 17, 1127-35.   DOI   ScienceOn
18 Su L, Zhou W, Asomaning K, et al (2006). Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer. Carcinogenesis, 27, 1024-9.   DOI   ScienceOn
19 Wei W, Liang X, Weng X (2007). The association of MMP-1-1607(1 G-2G) single nucleotide polymorpllism with the susceptibility to non-small cell lung carcinoma in Guizhou Han Nationality. JOURNAL OF GUIYANG MEDICAL COLLEGE, 32, 267-70.
20 Xiao H, Ding J, Gao S, et al (2011). Never smokers with lung cancer: analysis of genetic variants. Asian Pac J Cancer Prev, 12, 2807-9.
21 Yamamura T, Nakanishi K, Hiroi S, et al (2002). Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas. Lung Cancer, 35, 249-55.   DOI   ScienceOn
22 Attia J, Thakkinstian A, D'Este C (2003). Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology. J Clin Epidemiol, 56, 297-303.   DOI   ScienceOn
23 Brennan P, Hainaut P, Boffetta P (2011). Genetics of lung-cancer susceptibility. Lancet Oncol, 12, 399-408.   DOI   ScienceOn
24 Cheng X (2007). Correlation of single nucleotide polymorphism in the matrix metallola'oteinase-1 promoter region (-1607)1G/2G with risk of lung cancer. J Shangxi Med Univ, 38, 777-9.
25 Chen Y, Nixon NB, Dawes PT, et al (2012). Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP- 1 and -3 and disease activity in rheumatoid arthritis. Genes Immun, 13, 29-37.   DOI   ScienceOn
26 DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88.   DOI   ScienceOn
27 Egeblad M, Werb Z (2002). New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer, 2, 161-74.   DOI   ScienceOn
28 Fang S, Jin X, Wang R, et al (2005). Polymorphisms in the MMP1 and MMP3 promoter and non-small cell lung carcinoma in North China. Carcinogenesis, 26, 481-6.
29 Goldstraw P, Ball D, Jett JR, et al (2011). Non-small-cell lung cancer. Lancet, 378, 1727-40.   DOI   ScienceOn