Browse > Article
http://dx.doi.org/10.7314/APJCP.2012.13.11.5763

Lipid Peroxidation and Antioxidant Vitamin Status in Oral Cavity and Oropharyngeal Cancer Patients  

Marakala, Vijaya (Department of Biochemistry, Srinivas Institute of Medical Science and Research Centre)
Malathi, M. (Department of Biochemistry, Father Muller Medical College)
Shivashankara, A.R. (Department of Biochemistry, Father Muller Medical College)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.11, 2012 , pp. 5763-5765 More about this Journal
Abstract
Background: This study was conducted to determine levels of lipid peroxidation and antioxidant vitamin status in patients with oral cavity and oropharyngeal cancer. Methods: The study group consisted of a total number of 80 subjects between the age 40-68 years, 40 with clinically and histopathologically proved cases of oral cavity and oropharyngeal cancer and 40 normal healthy, age and sex matched volunteers as controls. Levels of lipid peroxidation products as malondialdehyde (MDA) and antioxidant vitamins as vitamin A and vitamin C were estimated and compared between the two groups. Results: There was a statistical significant difference in the mean MDA, plasma vitamin A and vitamin C in the oral and oropharyngeal cancer patients compared with the healthy controls (p<0.0001). Conclusions: Lipid peroxidation (MDA) is higher and plasma antioxidant vitamins like vitamin A and vitamin C were lower in oral cavity and oropharyngeal cancer patients than healthy controls.
Keywords
Oral cavity and oropharyngeal cancer; lipid peroxidation; malondialdehyde; vitamin A; vitamin C;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Reza Mi, Elnaz F, Ensiyeh S, et al (2009). Humana Press Inc., Friday, January 16, 2009.
2 Ames NB (1993). Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci, USA. 90, 7915-2.   DOI   ScienceOn
3 Bessey OA, Lowry OH, Brock MJ, et al (1946). The determination of vitamin A and carotene in small quantities of blood serum. J Biochem, 166, 177-8.
4 Ferlay J, Shin HR, Bray F, et al (2010). GLOBOCAN 2008 v1.2. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. Available at: globocan.iarc.fr [Accessed 2011].
5 Khanna R, Thapa PB, Khanna HD et al (2005). Lipid peroxidation and antioxidant enzyme status in oral carcinoma patients. Med J, 3, 334-9.
6 Lawal AO, Kolude B, Adeyemi BF et al (2012). Serum antioxidant vitamins and the risk of oral cancer in patients seen at a tertiary institution in Nigeria. Niger J Clin Pract, 15, 30-3.   DOI
7 Loft S, Poulsen HE (1996). Cancer risk and oxidative DNA damage in man. J Mol Med, 74, 297-2.   DOI   ScienceOn
8 Malathi M, Vijay M, Shivashankara AR (2011). The role of oxidative stress and the effect of radiotherapy on the plasma oxidant-antioxidant status in head and neck cancer. J Clinical and Diagnostic Res, 5, 249-1.
9 Masthan KMK, Babu NA, Dash KC, et al (2012). Advanced diagnostic aids in oral cancer. Asian Pac J Cancer Prev, 13, 3573-6.   DOI
10 Murray RK, Granner DK, Mayes PA, et al (2000). Harper's Biochemistry. 25th ed. Connecticut: Appleton and Lange; 2000. 169-0.
11 Murray RK, Granner DK, Mayes PA, et al (2009). Harper's Illustrated Biochemistry. 28th ed (2009). 962.
12 Nidash DH, Suchetha K, Mithra NH, et al (2012). Status of serum vitamin c level and lipid peroxidation in smokers and non smokers with oral cancer. RJPBCS, 3, 170-5
13 Nagao T, Ikeda N, Warnakulasuriya S, et al (2000). Serum antioxidant micronutrients and risk of oral leukoplakia among Japanese. Oncol, 36, 466-0
14 Nagini S, Saroja M (2001). Circulating lipid peroxides and antioxidants as biomarkers of tumour burden in patients with oral squamous cell carcinoma. J Biochem Mol Biol and Biophys, 5, 55-9.
15 Nisha, Ashuma S, Harbans L (2008). Some oxidative stress related parameters in patients with head and neck carcinoma. Indian J Clin Biochem, 23, 38-0.   DOI   ScienceOn
16 Ohkawa H, Ohishi N, Yagi K (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 95, 351-8.   DOI   ScienceOn
17 Omaye ST, Turnbull JD, Sauberlieh HE (1979). Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. In methods in enzymology. Enzymol, 62, 3-8.   DOI
18 Posner M (2003). Head and Neck Cancer. In World Cancer Report. IARCPress-WHO, 232-41.
19 Zhang Y, Chen SY, Hsu T, et al (2002). Immunohistochemical detection of malondialdehyde -DNA adducts in human oral mucosa cells. Carcinogenesis, 23, 207-1.   DOI
20 Vatanasapt P, Suwanrungruang K, Kamsaard S, et al (2011). Epidemiology of oral and pharyngeal cancers in Khon Kaen, thailand: a high incidence in females. Asian Pac J Cancer Prev, 12, 2505-8.
21 Zheng W, Blot WJ, Diamond EL, et al (1993). Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. Cancer Res, 53, 795-8
22 Zini A, Nasser N, Vered Y (2012). Oral and pharyngeal cancer among the Arab population in Israel from 1970-2006. Asian Pac J Cancer Prev, 13, 585-9.   DOI