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http://dx.doi.org/10.7314/APJCP.2012.13.11.5701

Anti-tumor Initiating Potential of Andrographolide in 7,12-dimethylbenz[a]anthracene Induced Hamster Buccal Pouch Carcinogenesis  

Manoharan, S. (Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University)
Singh, Arjun Kumar (Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University)
Suresh, K. (Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University)
Vasudevan, K. (Department of Zoology, Faculty of Science, Annamalai University)
Subhasini, R. (Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University)
Baskaran, N. (Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.11, 2012 , pp. 5701-5708 More about this Journal
Abstract
The aim of the study was to investigate the chemopreventive potential of andrographolide in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Oral tumors developed in the buccal pouch of golden Syrian hamsters at a 100% incidence on painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Marked abnormalities in the status of detoxification enzymes, lipid perxodiation and antioxidants were noticed in hamsters treated with DMBA alone. Oral administration of andrographolide at a dose of 50 mg/kg bw to hamsters treated with DMBA not only completely prevented the tumor formation but also restored the status of the above mentioned biomarkers. The present study thus demonstrates the chemopreventive potential of andrographolide in DMBA-induced hamster buccal pouch carcinogenesis, which is probably due to its antioxidant potential as well as modulating effect on xenobiotic metabolising enzymes during DMBA-induced oral carcinogenesis.
Keywords
Andrographolide; antioxidants; detoxification enzymes; oral cancer;
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