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http://dx.doi.org/10.7314/APJCP.2012.13.11.5691

No Association between the CDX2 G543C Polymorphism and Risk of Gastric Atrophy and Cancer  

Goto, Yasuyuki (Department of Preventive Medicine, Nagoya University Graduate School of Medicine)
Kato, Tsuyoshi (Department of Gastroenterology, Nagoya University Graduate School of Medicine)
Ando, Takafumi (Department of Gastroenterology, Nagoya University Graduate School of Medicine)
Goto, Hidemi (Department of Gastroenterology, Nagoya University Graduate School of Medicine)
Hamajima, Nobuyuki (Department of Preventive Medicine, Nagoya University Graduate School of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.11, 2012 , pp. 5691-5694 More about this Journal
Abstract
Ectopic expression of CDX2 in the stomach is closely associated with chronic Helicobacter pylori (H. pylori) infection and intestinal metaplasia. Whether CDX2 has tumor suppression or tumorigenesis potential remains to be elucidated. In this study, we investigated the association between the CDX2 G543C polymorphism (silent mutation) and the risk for H. pylori-induced gastric atrophy and cancer as well as H. pylori infection, using 454 Japanese subjects undergoing a health checkup and 202 gastric cancer patients. The frequency of the minor allele was the same as previously reported in China, but different from that reported in England. CDX2 G543C was not associated with risk of H. pylori infection, gastric atrophy, or gastric cancer, although the point estimate for non-cardiac differentiated gastric cancer as compared to controls with gastric atrophy was 2.22 (95%CI=0.17-29.4). In conclusion, our results indicate that the CDX2 G543C polymorphism is unlikely to affect the H. pylori infection-gastric atrophy-gastric cancer sequence.
Keywords
CDX2; polymorphism; Helicobacter pylori; gastric atrophy; gastric cancer;
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