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http://dx.doi.org/10.7314/APJCP.2012.13.11.5445

Role of Endocrine Disrupting Chemicals in the Occurrence of Benign Uterine Leiomyomata: Special Emphasis on AhR Tissue Levels  

Bidgoli, Sepideh Arbabi (Department of Toxicology and Pharmacology, Islamic Azad University, Pharmaceutical Sciences Branch (IAUPS))
Khorasani, Hoda (Department of Toxicology and Pharmacology, Islamic Azad University, Pharmaceutical Sciences Branch (IAUPS))
Keihan, Heideh (Department of Toxicology and Pharmacology, Islamic Azad University, Pharmaceutical Sciences Branch (IAUPS))
Sadeghipour, Alireza (Oncopathology Research Center, Department of Pathology, Rasool Akram University hospital, Tehran University of Medical Sciences (TUMS))
Mehdizadeh, Abolfazl (Department of Gynecology and obstetrics, Rasool Akram University hospital, Tehran University of Medical Sciences (TUMS))
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.11, 2012 , pp. 5445-5450 More about this Journal
Abstract
Although benign uterine leiomyomata (LMA) is the most common reproductive tumor in premenopausal women, its etiology is largely unknown. We aimed in the present study to demonstrate the potential role of environmental factors with estrogenic activity in tumor etiology by focusing on the role of aryl hydrocarbon receptor (AhR) which mediates the effects of many environmental endocrine disruptors and contributes to the loss of normal ovarian function in polluted environments. This case-control study aimed to compare the interactions between AhR and lifestyle factors in a clinical setting for the first time among 138 newly diagnosed LMA patients and 138 normal controls who lived in Tehran and Mashhad, respectively, during the last 10 years. To conduct immunohistochemical studies using appropriate monoclonal antibodies, 30 cases were selected retrospectively from 2009-2011 from the pathology departments of two university hospitals in Tehran. Although the levels of sex steroid receptors were similar in adjacent myometrium and uterine leiomyomas of all cases, AhR was significantly overexpressed (p=0.034, OR=1.667) in uterine LMA and this overexpression was correlated with living in Tehran [(p=0.04, OR=16 (1.216-210.58)], smoking[P=0.04, OR=2.085 (1.29-3.371)], living near polycyclic aromative hydrocarbon producing companies [p=0.007, OR=2.22 (1.256-3.926)] and eating grilled meat [p=0.042, OR=1.28 (1.92-3.842)]. Our study contributes to the understanding of the effects of EDCs on AhR levels as well as women's health and points out possible risk factors for the development and growth of uterine LMA. It seems that the development of LMA could be the result of interactions between hormonal and environmental factors.
Keywords
Uterine leiomyoma; leimyomata; aryl hydrocarbon receptor (AhR); ER; PR; AR; IHC;
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1 Anissa LM Turyk, Henry A, Sally F (2011). Victoria persky uterine leiomyomata in a cohort of great lakes sport fish consumers. Environ Res, 111, 565-72.   DOI
2 Azari MR Falaki F, Masoudi Nejad MR (2007). Assessment of dioxin-like compounds released. Tanaffos, 6, 59-64.
3 Balabanic D Rupnik M, Klemencic AK (2011). Negative impact of endocrine-disrupting compounds on human reproductive health. Reprod Fertil Dev, 23, 403-16.
4 Bidgoli SA Ahmadi R, Zavarhei MD (2010). Role of hormonal and environmental factors on early incidence of breast cancer in Iran. Sci Total Environ, 408, 4056-61.   DOI
5 Bidgoli SA, Eftekhari T (2011). Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. Asian Pac J Cancer Prev, 12, 1289-93.
6 Bidgoli SA Karimi M, Asami Z, Baher H, Djamali ZM (2011). Association between testicular aryl hydrocarbon receptor levels and idiopathic male infertility: a case-control study in Iran. Sci Total Environ, 409, 3267-73.   DOI
7 Bidgoli SA Korani M, Bozorgi N, Zavarhei MD, Ziarati P, Akbarzadeh S (2011). Association between glycodelin and aryl hydrocarbon receptor in Iranian breast cancer patients: impact of environmental endocrine disrupting chemicals Asian Pac J Cancer Prev, 12, 2431-5.
8 Brenda E, Marcella W, Steven S, et al (2007). Concentrations and risk of uterine leiomyoma in the seveso. Am J Epidemiol, 166, 79-87.   DOI
9 Eduardo FM Szklo, Neil R (2001). Risk factors for uterine leiomyoma: a practice-based case-control study. Am J Epidemiol, 1, 153.
10 Hunter DS, Hodges LC, Eagon PK, et al (2000). Influence of exogenous estrogen receptor ligands on uterine leiomyoma:evidence from an in vitro/in vivo animal model for uterine. Environ Hlth Perspect, 108, 829-34.   DOI
11 Kawaguchi K, Fujii S, Konishi I, et al (1991). Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki-67 in leiomyoma and myometrium during the menstrual cycle and pregnancy. Virchows Arch A Pathol Anat Histopathol, 419, 309-15.   DOI
12 Khorram O, Garthwaite M, Golos T (2002). Uterine and ovarian aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) mRNA expression in benign and malignant gynaecological conditions. Mol Hum Reprod, 8, 75-80.   DOI
13 Kubinova K, Mara M, Horak P, Kuzel D (2002). Genetic factors in etiology of uterine fibroids. Ceska Gynekol, 77, 58-60.
14 Marshall LM, Spiegelman D, Goldman MB, et al (1998). A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata. Fertil Steril, 70, 432-9.   DOI   ScienceOn
15 L Amant H, Sadeghi-Bazargani, H Abdollahi, F Ehdaeivand (2011). Uterine leiomyoma and its association with menstrual pattern and history of depo-medroxyprogesterone acetate injections. Int J General Med, 4, 535-8.
16 Leitao MM, Soslow RA, Nonaka D, et al (2004). Tissue microarray immunohistochemical expression of estrogen, progesterone, and androgen receptors in uterine leiomyomata and leiomyosarcoma. Cancer, 101, 1455-62.   DOI
17 Levy G, Hill MJ, Beall S, et al (2012). Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances. J Assist Reprod Genet.
18 S Okolo Incidence, aetiology and epidemiology of uterine fibroids. Best Pract Res Clin Obstet Gynaecol, 22, 571-88.
19 Samadi AR Lee NC, Flanders WD, Boring JR 3rd, Parris EB (1996). Risk factors for self-reported uterine fibroids: a case-control study. Am J Public Hlth, 86, 858-62.   DOI   ScienceOn
20 Sepideh AB, Tara E, Reza S (2011). Role of xenoestrogens and endogenous sources of estrogens on the occurrence of premenopausal breast cancer in Iran. Asian Pac J Cancer Prev, 12, 2425-30.
21 Shu Z, Chunhua Q, Stephen H (2003). Safe flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. Env Hlth Perspect, 111, 1877-82.   DOI   ScienceOn
22 Stapleton HM, Baker JE (2003). Arch Environ Contam Toxicol, 45, 227-34.   DOI
23 Valdez KE, Shi Z, Ting AY, Petroff BK (2009). Effect of chronic exposure to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin in female rats on ovarian gene expression. Reprod Toxicol, 28, 32-7.   DOI
24 Stapleton HM, Baker JE (2003). Comparing polybrominated diphenyl ether and polychlorinated biphenyl bioaccumulation in a food web in grand travers bay, lake Michigan. Arch Environ Contam Toxicol, 45, 227-34.   DOI
25 Sugiura-Ogasawara M, Ozaki Y, Sonta SI, Makino T, Suzumori K (2005). Exposure to bisphenol A is associated with recurrent miscarriage. Hum Reprod, 20, 2325-9.   DOI
26 Takeda T, Sakata M, Isobe A, et al (2008). Relationship between metabolic syndrome and uterine leiomyomas: a case-control study. Gynecol Obstet Invest, 66, 14-7.   DOI
27 Van der HE, Bechoux N, Muller M, et al (2009). Food flavonoid aryl hydrocarbon receptor-mediated agonistic/antagonistic/ synergic activities in human and rat reporter gene assays. Anal Chim Acta, 637, 337-45.   DOI
28 Wise LA, Palmer JR, Harlow BL, et al (2004). Reproductive factors, hormonal contraception, and risk of uterine leiomyomata in African-American women: a prospective study. Am J Epidemiol, 159, 113-23.   DOI
29 Wise LA, Radin RG, Palmer JR, et al (2011). Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata. Am J Clin Nutr, 94, 1620-31.   DOI
30 Zelieann R Craig, Wei Wang, Jodi A (2011). Flaws endocrinedisrupting chemicals in ovarian function: effects on steroidogenesis. Metabolism And Nuclear Receptor Signaling, 142, 633-46.