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http://dx.doi.org/10.5391/JKIIS.2012.22.6.786

Integrated Model Design of Microarray Data Using miRNA, PPI, Disease Information  

Ha, Kyung-Sik (Biomedical Knowledge Engineering Laboratory, Seoul National University)
Lim, Jin-Muk (Biomedical Knowledge Engineering Laboratory, Seoul National University)
Kim, Hong-Gee (Biomedical Knowledge Engineering Laboratory, Seoul National University)
Publication Information
Journal of the Korean Institute of Intelligent Systems / v.22, no.6, 2012 , pp. 786-792 More about this Journal
Abstract
A microarray is a collection of thousands of DNAs or RNAs arranged on a substrate, and it enables one to navigate large amounts of gene expression. However, a researcher uses his designed experimental methods to focus on particular phenotypes from the available mass of data. In this paper, we used MicroRNAs(miRNAs) and Protein-Protein Interation(PPI) databases to enhance and expand meanings in microarray data. Further, the expanded data are linked with the Online Mendelian Inheritance in Man(OMIM), and International Statistical Classification of Diseases and Related Health Problems, $10^{th}$ Revision(ICD-10), in order to extract common genetic relationships between diseases. This approach, we expect, should provide new biological views.
Keywords
micro-array; miRNA; PPI; Database; Prostate cancer;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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