Browse > Article
http://dx.doi.org/10.5391/JKIIS.2007.17.2.167

An Introduction of Two-Step K-means Clustering Applied to Microarray Data  

Park, Dae-Hoon (부산대학교 전기공학과)
Kim, Youn-Tae (부산대학교 전기공학과)
Kim, Sung-Shin (부산대학교 전기공학과)
Lee, Choon-Hwan (부산대학교 분자생물학과)
Publication Information
Journal of the Korean Institute of Intelligent Systems / v.17, no.2, 2007 , pp. 167-172 More about this Journal
Abstract
Long gene sequences and their products have been studied by many methods. The use of DNA(Deoxyribonucleic acid) microarray technology has resulted in an enormous amount of data, which has been difficult to analyze using typical research methods. This paper proposes that mass data be analyzed using division clustering with the K-means clustering algorithm. To demonstrate the superiority of the proposed method, it was used to analyze the microarray data from rice DNA. The results were compared to those of the existing K-meansmethod establishing that the proposed method is more useful in spite of the effective reduction of performance time.
Keywords
K-means Clustering; Microarray; Rice;
Citations & Related Records
연도 인용수 순위
  • Reference
1 P. Tamayo, D. Slonim, J. Mesirov, Q. Zhu, S. Kitareewan, E. Dmitrov sky, E. S. Lander and T. R. Golub, 'Interpreting patterns of gene expression with self- organizing maps : Methods and application to Hernatopoeitic differentiation,' Proceedings of National Academy of Sciences of the USA , vol.96, pp.2907- 2912, March 1999
2 M. B. Eisen, P. T. Spellman, P. O. Brown and D. Botstein, 'Cluster analysis and display of genome-wide expression patterns,' Proceedings of National Academy of Sciences of the USA , vol.95, pp.14863- 14868, December 1998
3 A. Ben-Der , R.. Shamir, Z. Yakhini, 'Clustering Gene Expression Patterns,' Journal of Computational Biology, 6:281- 297, July 14, 1999   DOI   ScienceOn
4 E. Hartuv, A. Schumitt, J. Lange, S. Meier-Ewert, H. Legrach and R. Shamir , 'An Algorithm for Clustering cDNAs for Gene Expression Analysis,' Proceedings of the Third International Conference on Computational Molecular Biology (RECOMB 99),pp.188- 197, 1999
5 http://gene-chips.com
6 A.K.Jain, M.N.Murty, and P.J.Flynn. 'Data clustering: A review,' ACM Computing Surveys, 31(3):264-323, September 1999   DOI   ScienceOn
7 황승용, 'DNA chip 기술,' 한국정보과학회지, 제18권 8호, pp .23- 28, 2000.8