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http://dx.doi.org/10.17555/jvc.2021.04.38.2.89

Magnetic Resonance Spectroscopy Findings in Perro de Presa Canario Dogs with Spongy Degeneration of the Central Nervous System

Hong, Sae-Byel (College of Veterinary Medicine, Chungnam National University)
Lee, In (Ian Animal Diagnostic Center)
Song, Yu-Mi (Ian Animal Diagnostic Center)
Lee, Young-Won (College of Veterinary Medicine, Chungnam National University)
Choi, Ho-Jung (College of Veterinary Medicine, Chungnam National University)

Publication Information

Journal of Veterinary Clinics / v.38, no.2, 2021 , pp. 89-93 More about this Journal

Abstract

2-Month-old, three related Perro de Presa Canario dogs were evaluated for similar neurological symptoms like circling, head pressing, depressed mental status, hypermetria, and vocalization. On magnetic resonance imaging (MRI) of the brain, there were large, bilaterally symmetrical lesions with involvement of thalamus, and brainstem that were T2- and FLAIR-hyperintense and T1-iso/hypointense. There was no inclusion of cerebellum. Single-voxel spectroscopy acquisition was located in the thalamus where abnormalities were found in MR images. The results of magnetic resonance spectroscopy (MRS) showed markedly decreased N-acetylaspartic acid value. Euthanasia was performed and lesions consistent with the canine spongy degeneration. Alteration in metabolites in the brain can be determined by MRS, which helps in diagnosing degeneration/leukodystrophy of the central nervous system in dogs.

Keywords

magenetic resonance spectroscopy; spongy degeneration; leukodystrophy; demyelination; dog;

Citations & Related Records

Reference

1	Summers BA, Cummings JF, de Lahunta A. Degenerative disease of the central nervous system. Veterinary neuropathology. Mosby: St Louis. 1995: 208-350.
2	Adachi M, Schneck L, Cara J, Volkb W. Spongy degeneration of the central nervous system (Van Bogaert and Bertrand type; Canavan's disease). Hum Pathol 1973; 4: 331-347. DOI
3	Choi S, Song Y, Lee K, Lee Y, Choi H. Multi-voxel magnetic resonance spectroscopy of cerebral metabolites in healthy dogs at 1.5 Tesla. J Vet Sci 2016; 17(2): 217-224. DOI
4	Coates JR, Kline KL. Congenital and inherited neurologic disorders in dogs and cats. In: JD Bonagura (ed.), Kirt's Current Veterinary Therapy XII. 12th ed. Philadelphia: Saunders WB 1995: 1111-1120.
5	Dewey CW. Encephalopathies: disorders of the brain. Dewey CW(ed): A practical Guide to Canine and Feline Neurology, Ames, IA, Iowa State Press 2003; 141-236.
6	Hagenfeldt L, Bollgren I, Venizelos N. N-Acetylasparticaciduria due to aspartoacylase deficiency-a new aetiology of childhood leukodystrophy. J Inherited Metab Dis 1987; 10: 135-141. DOI
7	Marks HG, Caro PA, Wang ZY, Detre JA, Bogdan AR, Gusnard DA, Zimmerman RA. Use of computed tomography, magnetic resonance imaging, and localized 1H magnetic resonance spectroscopy in Canavan's disease: A case report. Ann Neurol 1991; 30: 106-110. DOI
8	Jones BR, Alley MR, Shimada A, Lyon M. An encephalomyelopathy in related Birman kittens. N Z Vet J 1992; 40: 160-163. DOI
9	Karimzadeh P, Jafari N, Nejad Biglari H, Ahmadabadi F, Nemati H, Nasehi MM, Ghofrani M, Mollamohammadi M. The clinical features and Diagnosis of Canavan's disease: A case series of Iranian Patients. Iran J Child Neurol 2014; 8(3): 66-71.
10	Mariani CL, Clemmons RM, Graham JP, Phillips LA, Chrisman CL. Magnetic resonance imaging of spongy degeneration of the central nervous system in a Labrador Retriever. Vet Radiol Ultrasound 2001; 42(4): 285-290. DOI
11	Mascalchi M, Brugnoli R, Guerrini L, Belli G, Nistri M, Politi LS, Gavazzi C, Lolli F, Argenti G, Villari N. Single-voxel long TE 1H-MR spectroscopy of the Normal brainstem and cerebellum. J Magn Reson Imaging 2002; 16: 532-537. DOI
12	Morales C, Bernardini M, Pumarola M, Siso S. Familial spongy degeneration in Cocker Spaniel dogs. J Vet Intern Med 2001; 15: 72.
13	Soares DP, Law M. Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications. Clin Radiol 2009; 64: 12-21. DOI
14	Morrison JP, Schatzberg SJ, De Lahunta A, Ross JT, Bookbinder P, Summers BA. Oligodendroglial dysplasia in two Bullmastiff dogs. Vet Pathol 2006; 43: 29-35. DOI
15	One K, Kitagawa M, Ito D, Tanaka N, Watari T. Regional variations and age-related changes detected with magnetic resonance spectroscopy in the brain of healthy dogs. Am J Vet Res 2014; 75(2): 179-186. DOI
16	Ratai EM, Gilberto GR. Handbook of Clinical Neurology, Vol. 135 (3rd series): Clinical magnetic resonance spectroscopy of the central nervous system 2016: 93-116.