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http://dx.doi.org/10.17555/jvc.2016.08.33.4.246

Protective Effects of Blue Honeysuckle on Rat Hypothyroidism Induced by Propylthiouracil  

Lee, Woo-Yeol (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Yi, Seong-Joon (Department of Veterinary Anatomy, College of Veterinary Medicine, Kyungpook National University)
Yun, Sungho (Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University)
Lim, Mee-Kyung (School of Healthcare and Biotechnology, Kyungwoon University)
Lee, Keun-Woo (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Publication Information
Journal of Veterinary Clinics / v.33, no.5, 2016 , pp. 246-254 More about this Journal
Abstract
The objective of the present study is to determine whether blue honeysuckle lyophilized concentrated powder (BH) has favorable effects on hypothyroidism and related reproductive organ damage. Hypothyroidism was induced by 9 subcutaneous administration of propylthiouracil (PTU) for 28 days. Levothyroxine (LT4)-treated group was intraperitoneally injected with LT4 for the same period, while for BH (125, 250, and 500 mg/kg) or Flos Lonicerae lyophilized aqueous extract (LF, 250 mg/kg)-treated groups, the test materials were orally administrated for 42 days: two weeks before PTU injection and during PTU administration. The changes in serum thyroid hormone levels, serum male sex hormone levels, and testis antioxidant defense system were observed by histopathology of the thyroid gland, epididymis, prostate, and testis. The oral administrations of 125, 250, and 500 mg/kg of BH showed favorable effects compared to LF on hypothyroidism and related damages of reproductive organs through augmentation of the antioxidant defense system in the testis. In conclusion, BH is a promising new potent thyroid gland protecting agent.
Keywords
blue honeysuckle; hypothyroidism; propylthiouracil; rat;
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