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http://dx.doi.org/10.17555/jvc.2015.10.32.5.422

Effect of Medetomidine and Combination of Medetomidine/tiletamine/zolazepam and Medetomidine/tiletamine/zolazepam/tramadol on Echocardiographic Cardiac Contractility in Dogs  

Suh, Sang-IL (Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University)
Kim, Tae-Jun (Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University)
Lee, Eun-Chan (Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University)
Hyun, Changbaig (Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University)
Publication Information
Journal of Veterinary Clinics / v.32, no.5, 2015 , pp. 422-425 More about this Journal
Abstract
This study evaluated the myocardial performance on echocardiography after the sedation/anesthesia of medetomidine (D), the combination of medetomidine and tiletamine/zolazepam (DZ), and the combination of medetomidine, tiletamine/zolazepam and tramadol (DZT) in Beagle dogs. Ten healthy adult Beagle dogs (weighing $8.6{\pm}1.0kg$) were enrolled in this study. Heart rate (HR), fractional shortening (%FS), left ventricular ejection fraction (%LVEF), stroke volume (SV), cardiac output (CO), left ventricular internal diameter in systole (LVIDs) and left ventricular internal diameter in diastole (LVIDd) using M-mode echocardiography were measured prior to anesthesia, then every 10 min for 60 min. The HR, %FS, %LVEF, SV and CO were significantly decreased during sedation/anesthesia with D, DZ and DZT combination of anesthesia. Although those anesthetic protocols provided acceptable quality of sedation/anesthesia, levels of cardiovascular suppression were substantial and persistent and thus the continuous monitoring on vital signs should be accompanied in any situation. Close attention is required for dogs with pre-existing heart diseases, when those anesthetic protocols were applied.
Keywords
medetomidine; anesthesia; Domitor; tiletamine; tramadol; dog;
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1 Atkins CE, Curtis MB, McGuirk SM, Kittleson MD, Sato T and Snyder PS. The use of m-mode echocardiography in determining cardiac output in dogs with normal, low, and high output states: comparison to thermodilution method. Vet Radiol Ultrasound 1992; 33: 297-304.   DOI
2 Cattet MR, Caulkett NA, Polischuk SC, Ramsay MA. Reversible immobilization of free-ranging polar bears with medetomidine-zolazepam-tiletamine and atipamezole. J Wildl Dis 1997; 33: 611-617.   DOI
3 de Morais HS, Muir WW3rd. The effects of medetomidine on cardiac contractility in autonomically blocked dogs. Vet Surg 1995; 24: 356-364   DOI
4 Fabio L, Barbara S, Maria MF, Stefano Z, Teresa S, Paolo B. Clinical comparison of medetomidine-butorphanol, medetomidine-midazolam and midazolam-butorphanol for intramuscular premedication in the English bulldog. Ann Fac Medic Vet di Parma 2007; 27: 131-142.
5 Ferrari L, Turrini G, Rostello C, Guidi A, Casartelli A, Piaia A, Sartori M. Evaluation of two combination of Domitor, Zoletil100, and Euthatal to obtain long-term nonrecovery anesthesia in Spraque-Dawley rats. Am Assoc Lab Ani Sci 2005; 55: 256-264.
6 Grimm KA, Tranquilli WJ, Gross DR, Sisson DD, Bulmer BJ, Benson GJ, Greene SA, Martin-Jimenez T. Cardiopulmonary effects of fentanyl in conscious dogs and dogs sedated with a continuous rate infusion of medetomidine. Am J Vet Res 2005; 66: 1222-1226.   DOI
7 Ko JC, Payton M, Weil AB, Kitao T, Haydon T. Comparison of anesthetic and cardiorespiratory effects of tiletaminezolazepam-butorphanol and tiletamine-zolazepam-butorphanolmedetomidine in dogs. Vet Ther 2007; 8: 113-126.
8 Pypendop BH, Verstegen JP. Hemodynamic effects of medetomidine in the dog: a dose titration study. Vet Surg 1998; 27: 612-622.   DOI
9 Savvas I, Plevraki K, Raptopoulos D, Koutinas AF. Blood gas and acid-base status during tiletamine/zolazepam anaesthesia in dogs. Vet Anaesth Analg 2005; 32: 94-100.   DOI
10 Vettorato E, Zonca A, Isola M, Villa R, Gallo M, Ravasio G, Beccaglia M, Montesissa C, Cagnardi P. Pharmacokinetics and efficacy of intravenous and extradural tramadol in dogs. Vet J 2010; 183: 310-315.   DOI
11 Walzer C, Huber C. Partial antagonism of tiletamine-zolazepam anesthesia in cheetah. J Wildl Dis 2002; 38: 168-472.
12 Caulkett NA, Cattet MR. Physiological effects of medetomidine-zolazepam-tiletamine immobilization in black bears. J Wildl Dis 1997; 33: 611-617.   DOI
13 Hellyer P, Muir WW 3rd, Hubbell JA, Sally J. Cardiorespiratory effects of the intravenous administration of tiletamine-zolazepam to dogs. Vet Surg 1989; 18: 160-165.   DOI