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http://dx.doi.org/10.17555/jvc.2015.10.32.5.410

Evaluation of the Bone Defect Regeneration after Implantation with Cuttlebone in Rabbit  

Won, Sangcheol (College of Veterinary Medicine.Veterinary Medical Research Institute, Jeju National University)
Lee, Joo-Myoung (College of Veterinary Medicine.Veterinary Medical Research Institute, Jeju National University)
Park, Hyunjung (College of Veterinary Medicine.Veterinary Medical Research Institute, Jeju National University)
Seo, Jongpil (College of Veterinary Medicine.Veterinary Medical Research Institute, Jeju National University)
Cheong, Jongtae (College of Veterinary Medicine.Veterinary Medical Research Institute, Jeju National University)
Publication Information
Journal of Veterinary Clinics / v.32, no.5, 2015 , pp. 410-416 More about this Journal
Abstract
Bone grafting is widely used to bridge major bone defects or to promote bone union. In the evaluation of bone defect regeneration, 5 mm-diameter defects were created in rabbit calvaria. Concerning biocompatibility, fibrous capsule thickness of CBHA (hydroxyapatite from cuttlebone) was significantly thinner than that of CB (cuttlebone) and CHA (hydroxyapatite from coral) (p < 0.05) at 2 and 4 weeks after implantation. Concerning 12-week total changes of radiologic gray-level histogram, CBHA was significantly higher than CHA (p < 0.05). In the evaluation of bone defect regeneration, bone formation of CHA was significantly higher than that of CB and CBHA (p < 0.05). Based on the clinical and histological results, CBHA would be a safe material for use inside the body and has more effective osteoconduction than CB. It is suggested that CBHA is a valuable bone graft material.
Keywords
Bone graft; cuttlebone; hydroxyapatite; coral; scaffold;
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Times Cited By KSCI : 4  (Citation Analysis)
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