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http://dx.doi.org/10.17555/jvc.2015.08.32.4.301

Echocardiographic Evaluation of Cardiovascular Function in Cloned Dogs  

Yeo, Ju-Hwan (Department of Veterinary Dianostic Imaging, College of Veterinary Medicine, Konkuk University)
Kim, Jae-Hwan (Department of Veterinary Dianostic Imaging, College of Veterinary Medicine, Konkuk University)
Kim, So-Young (Department of Veterinary Dianostic Imaging, College of Veterinary Medicine, Konkuk University)
Lee, Seung-Jun (Department of Veterinary Dianostic Imaging, College of Veterinary Medicine, Konkuk University)
Park, Noh-Won (Department of Veterinary Dianostic Imaging, College of Veterinary Medicine, Konkuk University)
Oh, Hyun-Ju (Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University)
Kim, Min-Jung (Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University)
Kim, Geon-A (Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University)
Jo, Young-Kwang (Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University)
Lee, Byeong-Chun (Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University)
Eom, Kidong (Department of Veterinary Dianostic Imaging, College of Veterinary Medicine, Konkuk University)
Publication Information
Journal of Veterinary Clinics / v.32, no.4, 2015 , pp. 301-307 More about this Journal
Abstract
The purpose of this study was to compare echocardiographic parameters of cloned beagle dogs with the previously reported reference range. Seven cloned dogs were assessed for anatomical features and cardiac function through left- and right-sided heart and right ventricle outflow tract from M-mode, 2D-mode, pulsed wave Doppler and tissue Doppler imaging. In all the cloned dogs, there were no abnormalities in anatomical structure and measurements were within the normal reference range. In addition, left- and right-sided myocardial function was within the normal reference range. Especially, pulmonary hypertension and right-sided heart failure frequently encountered in cloned animals were not recognized in cloned dogs. In conclusion, no evidence of cardiovascular dysfunction in mature cloned dogs could be identified either at birth or the growing stage in this study. Therefore, serious adverse effects of somatic cell nuclear transfer technology including transgenesis on cardiac morphology and function were not found in cloned dogs.
Keywords
cloned beagle dogs; cardiovascular function; cardiac morphology;
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