Effects of Fucoidan on Nitric Oxide Production and Activator Protein-1 Activation in Lipopolysaccharide-Stimulated Porcine Peripheral Blood Mononuclear Cells
![]() |
Park, Jongchan
(Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University)
Ahn, Changhwan (Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University) Kang, Byeong-Teck (Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University) Kang, Ji-Houn (Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University) Jeung, Eui-Bae (Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University) Yang, Mhan-Pyo (Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University) |
1 |
Shan J, Fu J, Zhao Z, Kong X, Huang H, Luo L, Yin Z. Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264. 7 cells through suppressing NF- |
2 | Sorensen NS, Skovgaard K, Heegaard PM. Porcine blood mononuclear cell cytokine responses to PAMP molecules: comparison of mRNA and protein production. Vet Immunol Immunopathol 2011; 139: 296-302. DOI |
3 | Yang JW, Yoon SY, Oh SJ, Kim SK, Kang KW. Bifunctional effect of fucoidan on the expression of inducible nitric oxide synthase. Biochem Biophys Res Commun 2006; 346: 345-350. DOI |
4 | Yokota T, Nagashima M, Ghazizadeh M, Kawanami O. Increased effect of fucoidan on lipoprotein lipase secretion in adipocytes. Life Sci 2009; 84: 523-529. DOI |
5 | Baba M, Snoeck R, Pauwels R, De Clercq E. Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus. Antimicrob Agents Chemother 1988; 32: 1742-1745. DOI |
6 | Backstrom L, Hoefling DC, Morkoc AC, Cowart RP. Effect of atrophic rhinitis on growth rate in Illinois swine herds. J AVMA 1985; 187: 712-715. |
7 |
Choi RJ, Chun J, Khan S, Kim YS. Desoxyrhapontigenin, a potent anti-inflammatory phytochemical, inhibits LPSinduced inflammatory responses via suppressing NF- |
8 | Berteau O, Mulloy B. Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. Glycobiology 2003; 13: 29R-40R. DOI |
9 | Bilan MI, Grachev AA, Ustuzhanina NE, Shashkov AS, Nifantiev NE, Usov AI. Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag. Carbohydr Res 2002; 337: 719-730. DOI |
10 | Block ML, Zecca L, Hong JS. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature 2007; 8: 57-69. |
11 |
Chun J, Choi RJ, Khan S, Lee DS, Kim YC, Nam YJ, Kim YS. Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF- |
12 | Cui YQ, Zhang LJ, Zhang T, Luo DZ, Jia YJ, Guo ZX, Wang XM. Inhibitory effect of fucoidan on nitric oxide production in lipopolysaccharide-activated primary microglia. Clin Exp Pharmacol Physiol 2010; 37: 422-428. DOI |
13 | Cumashi A, Ushakova NA, Preobrazhenskaya ME, D'Incecco A, Piccoli A, Totani L, Nifantiev NE. A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology 2007; 17: 541-552. DOI |
14 | Dauphinee SM, Karsan A. Lipopolysaccharide signaling in endothelial cells. Lab Invest 2005; 86: 9-22. |
15 |
Kikuchi T, Hagiwara K, Honda Y, Gomi K, Kobayashi T, Takahashi H, Nukiwa T. Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF- |
16 | DeGroote MA, Fang FC. Antimicrobial properties of nitric oxide. In: Nitric oxide and infection, New York: Kluwer Academic Publishers, 2002: 231-261. |
17 | Irhimeh MR, Fitton JH, Lowenthal RM. Pilot clinical study to evaluate the anticoagulant activity of fucoidan. Blood Coagul Fibrin 2009; 20: 607-610. DOI |
18 | Iwakiri Y, Sampson DA, Allen KGD. Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by conjugated linoleic acid in murine macrophages. Prostag Leukotr Ess 2002; 67: 435-443. DOI |
19 |
Kim DI, Kim KH, Kang JH, Jung EM, Kim SS, Jeung EB, Yang MP. Trans-10, cis-12-conjugated linoleic acid modulates NF- |
20 | Koyanagi S, Tanigawa N, Nakagawa H, Soeda S, Shimeno H. Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities. Biochem Pharmacol 2003; 65: 173-179. DOI |
21 | Kroncke KD, Fehsel K, Kolb-Bachofen V. Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities. Biol Chem Hoppe Seyler 1995; 376: 327-343. |
22 |
Kwon DJ, Ju SM, Youn GS, Choi SY, Park J. Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF- |
23 |
Nakamura T, Suzuki H, Wada Y, Kodama T, Doi T. Fucoidan induces nitric oxide production via p38 mitogenactivated protein kinase and NF- |
24 | Li B, Lu F, Wei X, Zhao R. Fucoidan: structure and bioactivity. Molecules 2008; 13: 1671-1695. DOI |
25 |
Mankan AK, Lawless MW, Gray SG, Kelleher D, McManus R. NF- |
26 | Murphy S. Production of nitric oxide by glial cells: regulation and potential roles in the CNS. Glia 2000; 29: 1-13. DOI |
27 | Nathan C, Shiloh MU. Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc Natl Acad Sci USA 2000; 97: 8841-8848. DOI |
28 | Ohshima H, Bartsch H. Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat Res 1994; 305: 253-264. DOI |
29 | Pampusch MS, Bennaars AM, Harsch S, Murtaugh MP. Inducible nitric oxide synthase expression in porcine immune cells. Vet Immunol Immunopathol 1998; 61: 279-289. DOI |
30 |
Park HY, Han MH, Park C, Jin CY, Kim GY, Choi IW, Choi YH. Anti-inflammatory effects of fucoidan through inhibition of NF- |
31 |
Sarkar FH, Li Y, Wang Z, Kong D. NF- |
32 | Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene 2001; 20: 2390-2400. DOI |
33 | Chen YC, Shen SC, Lee WR, Hou WC, Yang LL, Lee TJ. Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages. J Cell Biochem 2001; 82: 537-548. DOI |
34 | Feng GJ, Goodridge HS, Harnett MM, Wei XQ, Nikolaev AV, Higson AP, Liew FY. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J Immunol 1999; 163: 6403-6412. |
35 | Noman AS, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Thalidomide inhibits lipopolysaccharide-induced nitric oxide production and prevents lipopolysaccharide-mediated lethality in mice. FEMS Immunol Med Microbiol 2009; 56: 204-211. DOI |
![]() |