Browse > Article

Ketoprofen Plaster Toxicity Induced Gastrointestinal Hemorrhage in a Dog  

Park, Hyung-Jin (College of the Veterinary Medicine, Chungnam National University)
Choi, Joon-Hyuk (College of the Veterinary Medicine, Chungnam National University)
Lee, Woo-Nam (College of the Veterinary Medicine, Chungnam National University)
Song, Kun-Ho (College of the Veterinary Medicine, Chungnam National University)
Seo, Kyoung-Won (College of the Veterinary Medicine, Chungnam National University)
Publication Information
Journal of Veterinary Clinics / v.31, no.3, 2014 , pp. 220-222 More about this Journal
Abstract
A 14 year-old Shih-tzu was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with a history of foreign body ingestion and vomiting. The vomitus contained ketoprofen plaster, which is used for orthopedic analgesia in humans. Supportive care and gastrointestinal (GI) protective agents were administered, including famotidine, misoprostol, sucralfate, omeprazole, and fluid therapy. However, the clinical signs worsened, and anemia, melena, leukocytosis, and azotemia developed. The patient was diagnosed with GI hemorrhage and underwent a whole blood transfusion followed by barium sulfate administration. After administering barium sulfate as a GI protectant, the clinical signs improved, and the patient was discharged.
Keywords
ketoprofen plaster; NSAID toxicity; barium sulfate;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Hur C, Chan AT, Tramontano AC, Gazelle GS. Coxibs versus combination NSAID and PPI therapy for chronic pain: an exploration of the risks, benefits, and costs. Ann Pharmacother 2006; 40: 1052-1063   DOI
2 Al Suleimani YM, Abdelrahman AM, AlMahruqi AS, Alhseini IS, Tageldin MH, Mansour ME, Ali BH. Interaction of nimesulide, a cyclooxygenase-2 inhibitor, with cisplatin in normotensive and spontaneously hypertensive rats. Food Chem Toxicol 2010; 48: 139-144.   DOI
3 Boston SE, Moens NM, Kruth SA, Southorn EP. Endoscopic evaluation of the gastroduodenal mucosa to determine the safety of short-term concurrent administration of meloxicam and dexamethasone in healthy dogs. Am J Vet Res 2003; 64: 1369-1375.   DOI
4 Granero GE, Amidon GL. Possibility of enterohepatic recycling of ketoprofen in dogs. Int J Pharm 2008; 349: 166-171.   DOI
5 Hackett T. Emergency approach to intoxications. Clin Tech Small Anim Pract 2000; 15: 82-87.   DOI
6 Heo SK, Cho J, Cheon JW, Choi MK, Im DS, Kim JJ, Choi YG, Jeon do Y, Chung SJ, Shim CK Kim DD. Pharmacokinetics and pharmacodynamics of ketoprofen plasters. Biopharm Drug Dispos 2008; 29: 37-44.   DOI
7 Jill EM, Stephen WP, David BC. Non-steroidal anti-inflammatory drugs. In: Small animal clinical pharmacology, 2nd ed. Philadelphia: WB Saunders. 2008: 287-308.
8 Koperna T, Kisser M, Reiner G, Schulz F. Diagnosis and treatment of bleeding colonic diverticula. Hepatogastroenterology 2001; 48: 702-705.
9 Lanas A, Panes J, Pique JM. Clinical implications of COX-1 and/or COX-2 inhibition for the distal gastrointestinal tract. Curr Pharm Des 2003; 9: 2253-2266.   DOI
10 Luna SPL, Basilio AC, Steagall PVM, Machado LP, Moutinho FQ, Takahira RK, Brandao CVS. Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs. Am J Vet Res 2007; 68: 258-264.   DOI
11 Myristate M. Final report on the safety assessment of myristyl myristate and isopropyl myristate. J Am Coll Toxicol 1982; 1: 55-80.   DOI
12 Reed S. Nonsteroidal anti-inflammatory drug-induced duodenal ulceration and perforation in a mature rottweiler. Can Vet J 2002; 43:971-972.
13 Papich MG. An update on nonsteroidal anti-inflammatory drugs (NSAIDs) in small animals. Vet Clin North Am Small Anim Pract 2008; 38: 1243-1266.   DOI
14 Plumb DC. Plumb's veterinary drug handbook, 6th ed. Iowa: Blackwell. 2008: 700-703.
15 Radi ZA. Pathophysiology of Cyclooxygenase Inhibition in Animal Models. Toxicol Pathol 2009; 37:34-46.   DOI
16 Rolf C, Engstrom B, Beauchard C, Jacobs LD, Le Liboux A. Intra-articular absorption and distribution of ketoprofen after topical plaster application and oral intake in 100 patients undergoing knee arthroscopy. Rheumatology 1999; 38: 564-567.   DOI   ScienceOn