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Photodynamic Therapy Using a 632 nm Diode Laser on Otitis Externa of the Dog  

Lee, Sug Man (Department of Biomedical Engineering, School of Medicine, Chungnam National University)
Cho, Eun-Sang (College of Veterinary school, Chungnam National University)
Lim, Hyun Soo (Department of Biomedical Engineering, School of Medicine, Chungnam National University)
Kim, Rachel (Gyeongnam National University of Science and Technology)
Son, Hwa-Young (College of Veterinary school, Chungnam National University)
Publication Information
Journal of Veterinary Clinics / v.31, no.1, 2014 , pp. 66-69 More about this Journal
Abstract
Photodynamic therapy (PDT) is an effective method for infectious disease, but as yet, no clinical trial on otitis externa has been conducted in animals. This report describes 4 cases of PDT treatment on severe otitis externa in canine. Four canines were treated with various concentrations of 5-aminolevulinic acid hydrochloride (5-ALA) and with various J (second ${\times}$ power) and irradiated by light-emitting diode light source at 635 nm, respectively. After the PDT applications, canines incubated in the dark for 5 or 6 hr. All patients showed clinical resolution of otitis externa after PDT treatment at the dose of 0.16~0.3 g ALA and J (54~162 $J/cm^2$). On the basis of these findings, PDT can be considered to be a new therapeutic approach to severe otitis externa in canine.
Keywords
photodynamic theraphy; otitis externa; canine; 5-aminolevulinic acid hydrochloride;
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