Browse > Article

Peripheral Giant Cell Granuloma in a Dog  

Cho, Eun-Sang (College of Veterinary Medicine, Chungnam National University)
Jeon, Sung-Joo (College of Veterinary Medicine, Chungnam National University)
Hong, Da-Hae (College of Veterinary Medicine, Chungnam National University)
Ryu, Si-Yun (College of Veterinary Medicine, Chungnam National University)
Jung, Ju-Young (College of Veterinary Medicine, Chungnam National University)
Park, Bae-Keun (College of Veterinary Medicine, Chungnam National University)
Son, Hwa-Young (College of Veterinary Medicine, Chungnam National University)
Publication Information
Journal of Veterinary Clinics / v.30, no.6, 2013 , pp. 478-481 More about this Journal
Abstract
A mass was detected in the oral cavity from a 18-year-old female miniature poodle dog. Grossly, the mass was soft to hard, red to purple, and $1.5{\times}1.5{\times}1cm$ in size. Histopathologically, the mass was composed of hyperplastic gingival epithelium, well-vascularized stroma, closely packed pleomorphic cells, and numerous giant cells with multiple nuclei and abundant eosinophilic cytoplasm. Immunohistochemically, tumor cells were positive for alkaline phosphatase and cytokeratin 7, but not positive for CD68 unlike in human. The mass was diagnosed to peripheral giant cell granuloma in oral cavity through typical clinical and histopathological features.
Keywords
peripheral giant cell granuloma; canine; alkaline phosphatase; cytokeratin 7; CD68;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Nakamura Y, Tanaka T, Wakimoto Y, Noda K, Kuwahara Y. Alkaline phosphatase activity in the osteoclasts induced by experimental tooth movement. J Electron Microsc 1991; 40: 403-406.
2 Svoboda O, Lojda Z, Skach M. Distribution of some enzymes in soft tissues of the oral cavity. J Dent Res 1959; 38: 443-450.   DOI   ScienceOn
3 Papagerakis P, Peuchmaur M, Hotton D, Ferkdadji L, Delmas P, Sasaki S, Tagaki T, Berdal A. Aberrant gene expression in epithelial cells of mixed odontogenic tumors. J Dent Res 1999; 78: 20-30.   DOI   ScienceOn
4 Ringler DJ. The digestive system. In: Veterinary pathology, 6th ed. Baltimore : Williams & Wilkins, 1997: 1043-1109.
5 Sandusky GE, Carlton WW, Wightman KA. Dagnostic immunohistochemistry of canine round cell tumors. Vet Pathol 1987; 24: 495-499.   DOI
6 Schildhaus HU, Dombrowski F. Undifferentiated (sarcomatous) carcinoma of the liver with osteoclast-like giant cells presenting as tumor thrombus in the inferior vena cava. Virshow Arch 2006; 448: 659-660.
7 Shimonishi M, Hatakeyama J, Sasano Y, Takahashi N, Uchida T, Kikuchi M, Komatsu M. In vitro differentiation of epithelial cells cultured from human periodontal ligament. J Periodontal Res 2007; 42: 456-465.   DOI   ScienceOn
8 Valentine BA, Eckhaus MA. Peripheral giant cell granuloma (giant cell epulis) in two dogs. Vet Pathol 1986; 23: 340-341.   DOI
9 Valentine BA, Flanders JA, Corapi WV, Rendano VT. Central giant cell granuloma in the mandible of a dog. J Am Vet Med Assoc 1988; 92: 657-658.
10 Verstraete FJ, Ligthelm AJ, Weber A. The histological nature of epulides in dogs. J Comp Pathol 1992; 106: 169-182.   DOI   ScienceOn
11 Withrow S, Vail D. The biology and pathogenesis of cancer. In: Withrow and MacEwen's small animal clinical oncology, 4th ed. Philadelphia: Saunders. 2006: 63-64.
12 Yoshida K, Yanai T, Iwasaki T, Sakai H, Ohta J, Kati S, Minami T, Lachner AA, Maseqi T. Cliniopathological study of canine oral epulides. J Vet Med Sci 1999; 61: 897-902.   DOI   ScienceOn
13 Gorlin RJ, Peterson WC. Oral disease in man and animals. Arch Dermatol 1967; 96: 390-403.   DOI
14 Abbas AK, Lichtman AH. Cellular and molecular immunology. 5th ed. Edinburg: Elsevier, 2005: 511.
15 Barker IK, Van dreumel AV, Palmer N. The alimentary system, In: Pathology of domestic animals, 4th ed. San Diego: Academic Press. 1997: 22-25.
16 Falaschini S, Ciavarella D, Mazzanti R, Di Cosola M, Turco M, Escudero N, Bascones A, Lo Muzio L. Peripheralgiant cell granuloma: immunohistochemical analysis of different markers. Study of three cases. Av Odontoestomatol 2007; 23: 189-196.
17 Gorrel G. Veterinary dentistry for the general practitioner. Edinburg: Elsevier. 2004: 109-110.
18 Hofmann MC, Jeltsch W, Brecher J, Walt H. Alkaline phosphatase isozyme in human testicular germ cell tumors. Their precancerous stage, and three related cell line. Cancer Res 1989; 49: 4696-4700.
19 Hong IH, Jeong WI, Son YS, Park JK, Yang HJ, Yuan DW, Goo MJ, Lee HR, Jeong KS. The ossifying epulis accompanying multi-nucleated giant cells in a dog. J Life Science 2007; 17: 1488-1491.   DOI   ScienceOn
20 Karayannopoulou M, Polizopoulou ZS, Koutinas AF, Fytianou A, Roubies N, Kaldrymidou E, Tsioli V, Patsikas MN, ConStantindis TC, Koutinas CK. Serum alkaline phosphatase isozyme activities in canine malignant mammary neoplasms with and without osseous transformation. Vet Clin Pathol 2006; 35: 297-290.
21 MaGavin MD, Zachary JF. Alimentary system. In: Pathologic basis of veterinary disease, 4th ed. Philadelphia: Mosby- Elsevier. 2007: 309-310.
22 Mathers ME, Pollock AM, March C, O'Donnell M. Cytokeratin 7: a useful adjunct in the diagnosis of chromophobe renal cell carcinoma. Histopathology 2002; 40: 563-567.   DOI   ScienceOn