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Cardiopulmonary and Oxidative Stress Effects of Lung Lobectomy in Dogs; Comparison of Open and Thoracoscopic Surgery  

Lee, Jae Yeon (Department of Veterinary Surgery, College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungbuk National University)
Kim, Myung Cheol (Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University)
Publication Information
Journal of Veterinary Clinics / v.30, no.6, 2013 , pp. 409-414 More about this Journal
Abstract
In the present study, we investigated and compared the cardiopulmonary and oxidative stress effects of dogs undergoing open and thoracoscopic lung lobectomy. Ten healthy dogs, 5-8 years old, weighing 9-12 kg were used. The animals were randomly assigned to one of two groups according to the type of surgical procedure; open (group 1, n=5) or thoracoscopic lung lobectomy (group 2, n=5). Cardiopulmonary parameters, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) concentrations were measured. There were statistically significant changes in arterial blood gases values in both groups. Total anesthesia and surgical times were significantly shorter in thoracoscopic lobectomy group compared with open surgery group. Increases in plasma SOD and CAT levels, and decreases in GPx levels were observed in both groups after surgery. Significant difference in GPx levels was found when the groups were compared. The GPx level was significantly lower in the thoracoscopic lobectomy group compared with the open surgery group.
Keywords
thoracoscopic lung lobectomy; cardiopulmonary effect; oxidative stress; dogs;
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1 Landreneau RJ, Hazelrigg SR, Mack MJ, Dowling RD, Burke D, Gavlick J, Perrino MK, Ritter PS, Bowers CM, DeFino J. Postoperative pain-related morbidity: Video-assisted thoracic surgery versus thoracotomy. Ann Thorac Surg 1993; 56: 1285-1289.   DOI   ScienceOn
2 Swanson SJ, Batirel HF. Video-assisted thoracic surgery (VATS) resection for lung cancer. Surg Clin North Am 2002; 82: 541-559.   DOI   ScienceOn
3 Thompson SE, Johnson JM. Analgesia in dogs after intercostals thoracotomy: a comparison of morphine, selective intercostals nerve block, and interpleural regional analgesia with bupivacaine. Vet Surg 1991; 20: 73-77.   DOI   ScienceOn
4 Walsh PJ, Remedios AM, Ferguson JF, Walker DD, Cantwell S, Duke T. Thoracoscopic versus open partial pericardectomy in dogs: comparison of postoperative pain and morbidity. Vet Surg 1999; 28: 472-479.   DOI   ScienceOn
5 MacPhail CM, Monnet E, Twedt DC. Thoracoscopic correction of persistent right aortic arch in a dog. J Am Anim Hosp Assoc 2001; 37: 577-581.   DOI
6 Michels C, Raes M, Toussaint O, Remacle J. Importance of Se-glutathione peroxidase, catalase, and Cu/Zn SOD for cell survival against oxidative stress. Free Radic Biol Med 1994; 17: 235-248.   DOI   ScienceOn
7 Radlinsky MG, Mason DE, Biller DS, Biller DS, Olsen D. Thoracoscopic visualization and ligation of the thoracic duct in dogs. Vet Surg 2002; 31: 138-146.   DOI   ScienceOn
8 Roviaro G, Varoli F, Vergani C, Maciocco M. State of the art in thoracoscopic surgery. Surg Endoscopy 2002; 16: 881-892.   DOI
9 Sies, H. Oxidative stress: oxidants and antioxidants. Exp Physiol 1997; 82: 291-295.   DOI
10 Stipancic I, Zarkovic N, Servis D, Sabolovic S, Tatzber F, Busic Z. Oxidative stress markers after laparoscopic and open cholecystectomy. J Laparoendosc Adv Surg Tech A 2005; 15: 347-352.   DOI   ScienceOn
11 Stobie D, Caywood DD, Rozanski EA, Bing DR, Dhokarikar P, Raffe MR, Kannan MS, King VL, Hegstad RL, Randall DA. Evaluation of pulmonary function and analgesia in dogs after intercostals thoracotomy and use of morphine administered intramuscularly or intrapleurally and bupivacaine administered intrapleurally. Am J Vet Res 1995; 56: 1098-1109.
12 Dupre GP, Corlouer JP, Bouvy B. Thoracoscopic pericardectomy performed without pulmonary exclusion in 9 dogs. Vet Surg 2001; 30: 21-27.   DOI   ScienceOn
13 Hazelrigg SR, Landreneau RJ, Boley TM, Priesmeyer M, Schmaltz RA, Nawarawong W, Johnson JA, Walls JT, Curtis JJ. The effect of muscle-sparing versus standard posterolateral thoracotomy on pulmonary function, muscle strength, and postoperative pain. J Thorac Cardiovasc Surg 1991; 101: 394-401.
14 Isakow K, Fowler D, Walsh P. Video-assisted thoracoscopic division of the ligamentum arteriosum in two dogs with persistent right aortic arch. J Am Vet Med Assoc 2000; 217: 1333-1337.   DOI   ScienceOn
15 Koksal H, Kurban S. Total oxidant status, total antioxidant status, and paraoxonase and arylesterase activities during laparoscopic cholecystectomy. Clinics 2010; 65: 285-290.   DOI   ScienceOn
16 Lansdowne JL, Monnet E, Twedt DC, Dernell WS. Thoracoscopic lung lobectomy for treatment of lung tumors in dogs. Vet Surg 2005; 34: 530-535.   DOI   ScienceOn
17 Lin J, Iannettoni MD. The role of thoracoscopy in the management of lung cancer. Surg Oncol 2003; 12: 195-200.   DOI   ScienceOn
18 Roviaro G, Varoli F, Vergani C, Nucca O, Maciocco M, Grignani F. Long-term survival after videothoracoscopic lobectomy for stage I lung cancer. Chest 2004; 126: 725-732.   DOI   ScienceOn
19 Borenstein N, Behr L, Chetboul V, Tessier D, Nicole A, Jacquet J, Carlos C, Retortillo J, Fayolle P, Pouchelon JL, Daniel P, Laborde F. Minimally invasive patent ductus arteriosus occlusion in 5 dogs. Vet Surg 2004; 33: 309-313.   DOI   ScienceOn