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A Case of Long-Term Management of Insulinoma in a Maltese Dog  

Park, So-Young (College of Veterinary Medicine, Chungbuk National University)
Kang, Byeong-Teck (College of Veterinary Medicine, Chungbuk National University)
Kang, Ji-Houn (College of Veterinary Medicine, Chungbuk National University)
Chang, Dongwoo (College of Veterinary Medicine, Chungbuk National University)
Yang, Mhan-Pyo (College of Veterinary Medicine, Chungbuk National University)
Publication Information
Journal of Veterinary Clinics / v.30, no.5, 2013 , pp. 363-365 More about this Journal
Abstract
A 15-year-old, spayed female Maltese dog weighing 2.80 kg was referred with seizure of unknown origin. At presentation, serum biochemistry showed marked hypoglycemia (46 mg/dL; reference interval [RI], 65-118 mg/dL). There were, however, no abnormalities on electrolytes, complete blood counts, urinalysis, survey radiographs, and abdominal ultrasonography. In the adrenocorticotropic hormone (ACTH) stimulation test, pre-ACTH and post-ACTH cortisol concentrations were within normal reference ranges. Serum insulin level was normal and fructosamine level was slightly lower than reference ranges. The clinical signs, including seizure and collapse caused by hypoglycemia, were gradually resolved with oral administration of prednisolone (PDS) twice daily. Forty five weeks later, serum biochemistry revealed hypoglycemia with markedly increased insulin level. On abdominal ultrasonography, increased heterogenous echogenecity with hypoechoic lesion was found within pancreatic parenchyma. Based on these findings, the dog was presumptively diagnosed to insulinoma. Hypoglycemic seizure was resolved with higher dose of PDS (1 mg/kg, q12h). At 688 days after first presentation, the patient was still alive without recurrence of hypoglycemic seizure. This case describes long-term management with PDS monotherapy in a Maltese dog with insulinoma.
Keywords
dog; insulin; insulinoma; prednisolone; hypoglycemia;
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