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Evaluation of Plasma NT-proBNP Concentration in Dogs with Chronic Mitral Valve Insufficiency  

Lee, Seunggon (Cardiology Services, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, North Carolina State University)
Hyun, Changbaig (Section of Small Animal Internal Medicine, School of Veterinary Medicine and Institute of Veterinary Medicine, Kangwon National University)
Publication Information
Journal of Veterinary Clinics / v.30, no.3, 2013 , pp. 151-158 More about this Journal
Abstract
This study aimed to evaluate the plasma concentration of NT-proBNP in dogs with different stages of heart failure by chronic mitral valve insufficiency (CMVI). Fifty small-breed dogs with CMVI and 7 healthy control dogs without cardiac disease and critical systemic diseases were included in the study population. As a preliminary study, we compared the plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the echocardiographic parameters between dogs of the International Small Animal Cardiac Health Council (ISACHC) classes. Then, we evaluated the associations between NT-proBNP and echocardiographic parameters. Plasma NT-proBNP levels showed a significant difference among the ISACHC groups. In the comparison between echocardiographic parameters and NT-proBNP, NT-proBNP were found to be associated with left atrium/aorta (LA/AO), early diastolic transmitral flow (E) velocity, late diastolic transmitral flow (A) velocity, end diastolic volume index (EDVI). Our study found plasma NT-proBNP might be useful to predict the disease progression in dogs with CMVI.
Keywords
Echocardiography; NT-proBNP; A flow velocity; dogs; CMVI;
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