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An Influence of a Combined Administration of Propofol and Isoflurane on Antioxidative Enzyme Activities in Growing Swine Erythrocytes  

Lee, Jae Yeon (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University)
Kim, Myung Cheol (College of Veterinary Medicine.Research Institute of Veterinary Medicine, Chungnam National University)
Publication Information
Journal of Veterinary Clinics / v.29, no.6, 2012 , pp. 460-463 More about this Journal
Abstract
The present study was aimed to evaluate and compare the oxidative stress status of isoflurane and propofol in pigs undergoing surgery with measuring the activities of antioxidant enzymes. The pigs were divided into 2 groups according to the type of anesthesia used for the surgical procedure. In the isoflurane group (group 1), anesthesia was induced and maintained with 2-2.5% isoflurane under 100% oxygen. The propofol group (group 2) received 8 mg/kg/h of IV propofol with 0.5-1% isoflurane under 100% oxygen. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities of isoflurane group were significantly lower at the end of surgery than at induction of anesthesia, while that of the propofol group maintained their baseline values. There were significant differences in all enzymes activities between groups at the end of surgery. These results indicate that propofol is capable of preserving the antioxidant capacity in pigs anesthetized with the combination of isoflurane and propofol infusion.
Keywords
antioxidant effects; isoflurane; oxidative stress; pigs; propofol;
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1 Plummer JL, Beckwith AL, Bastin FN, Adams JF, Cousins MJ, Hall P. Free radical formation in vivo and hepatotoxicity due to anesthesia with halothane. Anesthesiology 1982; 57:160-166.   DOI   ScienceOn
2 Allaouchiche B, Debon R, Goudable J, Chassard D, Duflo F. Oxidative stress status during exposure to propofol, sevoflurane and desflurane. Anesth Analg 2001; 93: 981-985.   DOI   ScienceOn
3 Aarts L, van der Hee R, Dekker I, de Jong J, Langemeijer H, Bast A. The widely used anesthetic agent propofol can replace alpha-tocopherol as an antioxidant. FEBS Letters 1995; 2: 83-85.
4 De La Cruz JP, Sedeño G, Carmona JA, Sánchez de la Cuesta F. The in vitro effects of propofol on tissular oxidative stress in the rat. Anesth Analg 1998; 87: 1141-1146.
5 De La Cruz JP, Zanca A, Carmona JA, de la Cuesta FS. The effect of propofol on oxidative stress in platelets from surgical patients. Anesth Analg 1999; 89: 1050-1055.
6 Halliwell B. Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med 1991; 30: 14S-22S.
7 Kato R, Foex P. Myocardial protection by anesthetic agents against ischemia-reperfusion injury: an update for anesthesiologists. Can J Anesth 2002; 49: 777-791.   DOI   ScienceOn
8 Kobayashi K, Yoshino F, Takahashi SS, Todoki K, Maehata Y, Komatsu T, Yoshida K, Lee MC. Direct assessments of the antioxidant effects of propofol medium chain triglyceride/ long chain triglyceride on the brain of stroke-prone spontaneously hypertensive rats using electron spin resonance spectroscopy. Anesthesiology 2008; 109: 426-435.   DOI   ScienceOn
9 Koksal H, Kurban S. Total oxidant status, total antioxidant status, and paraoxonase and arylesterase activities during laparoscopic cholecystectomy. Clinics 2010; 65: 285-290.   DOI   ScienceOn
10 Michels C, Raes M, Toussaint O, Remacle J. Importance of Se-glutathione peroxidase, catalase, and Cu/Zn SOD for cell survival against oxidative stress. Free Radic Biol Med 1994;17: 235-248.   DOI   ScienceOn