Browse > Article

Prostatic Adenocarcinoma in a Schnauzer Dog  

Hwang, Yong-Hyun (Pet's all animal hospital)
Choi, Woo (Pet's all animal hospital)
Kim, Na-Hyun (Department of Veterinary Pathology, Small Animal Tumor Diagnostic Centre, College of Veterinary Medicine Konkuk University)
Sur, Jung-Hyang (Department of Veterinary Pathology, Small Animal Tumor Diagnostic Centre, College of Veterinary Medicine Konkuk University)
Lee, Jae-Hoon (Department of Veterinary Surgery, College of Veterinary Medicine, Gyeongsang National University)
Publication Information
Journal of Veterinary Clinics / v.29, no.3, 2012 , pp. 250-254 More about this Journal
Abstract
An eight-year-old, castrated male, a Schnauzer dog was presented with dysuria, hematuria and intermittent vomiting. Retrograde positive contrast urethrography was performed under fluoroscope. On the contrast examination, the leakage was observed in the prostatic urethra region and irregular filling defect was also shown from the prostatic urethra and the level of the trigon of the bladder. Surgical treatment was selected because of partial urethral obstruction and dysuria. The metastasis at the time of surgery was suspected, and the owner decided euthanasia. We detected lymph metastasis with immunohistochemical staining for pan-cytokeratins (CK) AE1/AE3, confirming their epithelial origin. This report described typical clinical findings, diagnostic imaging and histopathological examination of a prostatic adenocarcinoma.
Keywords
prostate; adenocarcinoma; dog; cytokeratin AE1/AE3;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Schilling D, Hennenlotter J, Gakis G, Schwentner C, Kuehs U, Stenzl A, Sotlar K. Prospective assessment of histological serial sectioning of pelvic lymph nodes in prostate cancer: a cost-benefit analysis. BJU int 2012. doi: 10.1111/j.1464-410X.2012.10928.x.
2 Basinger RR, Robinette C, Spaulding KA. Prostate; In: Textbook of small animal surgery. Philadelphia: Saunders. 2003: 1542-1557.
3 Teske E, Naan EC, van Dijk EM, Van Garderen E, Schalken JA. Canine prostate carcinoma: epidemiological evidence of an increased risk in castrated dogs. Mol Cell Endocrinol 2002; 197: 251-255.   DOI   ScienceOn
4 Tseng SC, Jarvinen MJ, Nelson WG, Huang JW, Woodcock- Mitchell J, Sun TT. Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies. Cell 1982; 30: 361-372.   DOI   ScienceOn
5 van Leenders G, Dijkman H, Hulsbergen-van de Kaa C, Ruiter D, Schalken J. Demonstration of intermediate cells during human prostate epithelial differentiation in situ and in vitro using triple-staining confocal scanning microscopy. Lab Invest 2000; 80: 1251-1258.   DOI   ScienceOn
6 White RA. Prostatic surgery in the dog. Clin Tech Small Anim Pract 2000; 15: 46-51.   DOI   ScienceOn
7 Barsanti JA, Finco DR. Canine prostatic diseases. Vet Clin North Am Small Anim Pract 1986; 16: 587-599.   DOI
8 Bryan JN, Keeler MR, Henry CJ, Bryan ME, Hahn AW, Caldwell CW. A population study of neutering status as a risk factor for canine prostate cancer. Prostate 2007; 67: 1174-1181.   DOI   ScienceOn
9 Cornell KK, Bostwick DG, Cooley DM, Hall G, Harvey HJ, Hendrick MJ, Pauli BU, Render JA, Stoica G, Sweet DC, Waters DJ. Clinical and pathologic aspects of spontaneous canine prostate carcinoma: a retrospective analysis of 76 cases. Prostate 2000; 45: 173-183.   DOI   ScienceOn
10 Garraway LA, Lin D, Signoretti S, Waltregny D, Dilks J, Bhattacharya N, Loda M. Intermediate basal cells of the prostate: in vitro and in vivo characterization. Prostate 2003; 55: 206-218.   DOI   ScienceOn
11 Gobello C, Corrada Y. Noninfectious prostatic diseases in dogs Compend Contin Educ Vet 2002; 24: 99-107.
12 Lai CL, van den Ham R, van Leenders G, van der Lugt J, Teske E. Comparative characterization of the canine normal prostate in intact and castrated animals. Prostate 2008; 68: 498-507.   DOI   ScienceOn
13 Johnston SD, Root Kustritz, M.V. Olson PN. Clinical approach to infertility in the male dog. In: Canine and feline theriogenology: WB Saunders: 2001: 370-387.
14 Krawiec DR, Heflin D. Study of prostatic disease in dogs: 177 cases (1981-1986). J Am Vet Med Assoc 1992; 200: 1119-1122.
15 Lai CL, van den Ham R, van Leenders G, van der Lugt J, Mol JA, Teske E. Histopathological and immunohistochemical characterization of canine prostate cancer. Prostate 2008; 68: 477-488.   DOI   ScienceOn
16 Memon MA. Common causes of male dog infertility. Theriogenology 2007; 68: 322-328.   DOI   ScienceOn
17 Moll R, Franke WW, Schiller DL, Geiger B, Krepler R. The catalog of human cytokeratins: patterns of expression in nor-mal epithelia, tumors and cultured cells. Cell 1982; 31: 11-24.   DOI   ScienceOn
18 Mukaratirwa S, Chitura T. Canine subclinical prostatic disease: histological prevalence and validity of digital rectal examination as a screening test. J S Afr Vet Assoc 2007; 78: 66-68.
19 Obradovich J, Walshaw R, Goullaud E. The influence of castration on the development of prostatic carcinoma in the dog. 43 cases (1978-1985). J Vet Intern Med 1987; 1: 183-187.   DOI
20 Robinson EJ, Neal DE, Collins AT. Basal cells are progenitors of luminal cells in primary cultures of differentiating human prostatic epithelium. Prostate 1998; 37: 149-160.   DOI   ScienceOn
21 Russo M, Vignoli M, Catone G, Rossi F, Attanasi G, England GC. Prostatic perfusion in the dog using contrastenhanced Doppler ultrasound. Reprod Domest Anim 2009; 44:Suppl 2: 334-335.   DOI