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Profile of the Staphylococcal Exotoxin Gene and its Relation with Canine Atopic Dermatitis  

Nam, Eui-Hwa (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Chung, Tae-Ho (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Kim, Ji-Hyun (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Park, Seol-Hee (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Kim, Hyo-Eun (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Youn, Hwa-Young (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Chae, Joon-Seok (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Park, Yong-Ho (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Hwang, Cheol-Yong (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Publication Information
Journal of Veterinary Clinics / v.28, no.2, 2011 , pp. 196-203 More about this Journal
Abstract
Staphylococcus spp. is one of the most common bacteria isolated from the lesions of atopic dermatitis (AD) in humans, and their colonization is known to be a possible trigger factor of clinical signs. The aim of this study was to determine the prevalence of Staphylococcus spp. in canine AD (CAD), the types of exotoxins present, and their relation with the clinical severity of CAD. From 79 dogs with AD, 72 samples of Staphylococcus spp. were isolated (91.1%), and 65 (90.3%) were confirmed as Staphylococcus pseudintermedius. Concerning the profile of the exotoxin gene, 50 isolates (69.4%) contained at least one exotoxin gene, and 28 isolates (56%) were found to contain more than 2 different exotoxins. There was a significant difference in clinical severity with the presence of staphylococcal exotoxins (P=0.028), whereas no correlation was found with the presence of Staphylococcus spp. (P=0.598). The clinical severity of CAD increased only in relation to staphylococcal enterotoxin D (SED) and exfoliative toxins (P<0.05). Some clinical evaluation criteria (erythema, papule/pustule) were correlated with the presence of the exotoxin gene (P<0.05). This study showed that the high prevalence of Staphylococcus spp. and staphylococcal exotoxins in lesions from dogs with AD may be regarded as an important trigger factor for exacerbation of the clinical signs of CAD.
Keywords
Atopic dermatitis; dog; exotoxin; Staphylococcus;
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