Browse > Article

Meningoencephalitis in Dachshund Dog with Canine Distemper Virus Infection: 1.5 T and 7.0 T MRI Findings  

Kang, Min-Hee (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Deseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Park, Hee-Myung (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Deseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Publication Information
Journal of Veterinary Clinics / v.27, no.6, 2010 , pp. 755-759 More about this Journal
Abstract
A 6-year-old, intact female Dachshund was presented with generalized seizure for 2 days. Based on the neurologic and physical examinations, intracranial diseases were suspected. 1.5T and 7.0T magnetic resonance imaging (MRI) of the brain were taken. The MRI results revealed diffuse hyperintense lesions in the area of the diencephalon to the medulla oblongata in the T2-weighted images. Canine distemper virus-induced meningoencephalitis was confirmed by the result of RT-PCR of the cerebrospinal fluid (CSF). The dog was euthanized 7 days after diagnosis due to poor prognosis and clinical deterioration. Postmortem histopathologic examination was consistent with the MRI findings. This is the first case report using 1.5T and 7.0T MRI to compare the virus-induced intracranial lesions in meningoencephalitis.
Keywords
dog; CDV; MRI; 7 T;
Citations & Related Records

Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 McGowan JC, Haskins M, Wenger DA, Vite C. Investigating demyelination in the brain in a canine model of globoid cell leukodystrophy (Krabbe disease) using magnetization transfer contrast: preliminary results. J Comput Assist Tomogr 2000; 24: 316-321.   DOI   ScienceOn
2 Vandevelde M, Zurbriggen A. Demyelination in canine distemper virus infection: a review. Acta Neuropathol 2005; 109: 56-68.   DOI   ScienceOn
3 Lamb CR, Croson PJ, Cappello R, Cherubini GB. Results of MR imaging of the head in dogs with inflammatory cerebrospinal fluid. Vet Radiol Ultrasound 2005; 37: 424-427.
4 Lobetti RG, Pearson J. Magnetic resonance imaging in the diagnosis of focal granulomatous meningoencephalitis in two dogs. Vet Radiol Ultrasound 1996; 37: 424-427.   DOI   ScienceOn
5 Muller CF, Fatzer RS, Beck K, Vandevelde M, Zurbriggen A. Studies on canine distemper virus persistence in the central nervous system. Acta Neuropathologica 1995; 89: 438-445.   DOI   ScienceOn
6 Schobesberger M, Zurbriggen A, Doherr MG, Wessenbock H, Vandevelde M, Lassmann H, Griot C. Demyelination precedes oligodendrocyte loss in canine distemper virus-induced encephalitis. Acta Neuropathol 2002; 103: 11-19.   DOI   ScienceOn
7 Vandervelde M, Zurbriggen A. The neurobiology of canine distemper virus infection. Vet Microbiol 1995; 44: 271-280.   DOI
8 Atkins GJ, McQuaid S, Morris-Downes MM, Galbraith SE, Amor S, Cosby SL, Sheahan BJ. Transient virus infection and multiple sclerosis. Rev Med Virol 2000; 10: 291-303.   DOI   ScienceOn
9 Percy AK, Odrezin GT, Knowles PD, Rouah E , Armstrong DD. Globoid cell leukodystrophy: comparison of neuropathology with magnetic resonance imaging. Acta Neuropathologica 1994; 88: 26-32.   DOI   ScienceOn
10 Plummer SB, Wheeler SJ, Thrall DE, Kornegay JN. Computed tomography of primary inflammatory brain disorders in dogs and cats. Vet Radiol Ultrasound 1992; 33: 307-312.   DOI
11 Sheldon JJ, Siddharthan R, Tobias J, Sheremata WA, Solila K, Viamonte M. MR imaging of multiple sclerosis: comparison with clinical and CT examination in 74 patients. Am J Roentgenol 1985; 145: 957-964.   DOI   ScienceOn
12 Thomas WB, Sorjonen DC, Stesis JE. A retrospective evaluation of 38 cases of canine distemper encephalomyelitis. J Am Anim Hosp Assoc 1993; 29: 23-28.
13 Barkovich AJ. Concepts of myelin and myelination in neuroradiology. Am J Neuroradiol 2000; 21: 1099-1109.
14 Thomas WB. Inflammatory disease of the central nervous system in dogs. Clin Tech Small Anim Pract 1998; 13: 167-178.   DOI   ScienceOn
15 Tipold A, Vandevelde M, Jaggy A. Neurological manifestations of canine distemper infection. J small Anim Prac 1992; 33: 466-470.   DOI
16 Tipold A: Diagnosis of inflammatory and infectious disease of the central nervous system in dogs: a retrospective study. J Vet Int Med 1995; 9: 340-314.
17 Bathen-Noethen A, Stein VM, Puff C, Baumgaertner W, Tipold A. Magnetic resonance imaging findings in acute canine distemper virus infection. J Small Anim Pract 2008; 49: 460-467.   DOI
18 Cherubini GB, Mantis P, Martinez TA, Lamb CR, Cappello R. Utility of magnetic resonance imaging for distinguishing neoplastic from non-neoplastic brain lesions in dogs and cats. Vet Radiol Ultrasound 2005; 46: 384-387.   DOI   ScienceOn
19 Grossman RI, Gonzales-Scarano F, Atlas SW, Galetta S, Silberberg DH Multiple sclerosis: gadolinium enhancement in MR imaging. Radiology 1986; 161: 721-725.
20 Koutinas AF, Polizopoulou ZS, Baumgartner W, Lekkas S, Kontos V. Relation of clinical signs to pathological changes in 19 cases of canine distemper encephalomyelitis. J Comp Pathol 2002; 126: 47-56.   DOI   ScienceOn