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Autosomal-dominant Polycystic Kidney Disease in a Family of Scottish Fold Cats  

Seo, Kyoung-Won (College of Veterinary Medicine, Seoul National University)
Kim, Sae-Um (Namyangju Animal Hospital)
Ahn, Jin-Ok (College of Veterinary Medicine, Seoul National University)
Coh, Ye-Rin (College of Veterinary Medicine, Seoul National University)
Han, Sung-Young (Namyangju Animal Hospital)
Youn, Hwa-Young (College of Veterinary Medicine, Seoul National University)
Publication Information
Journal of Veterinary Clinics / v.27, no.6, 2010 , pp. 726-728 More about this Journal
Abstract
Autosomal-dominant polycystic kidney disease (AD-PKD) is common in Persian and Persian-related breeds, and is sporadically reported in Scottish Fold cats. A 5-year-old male Scottish Fold cat was diagnosed with polycystic kidney disease based on screening tests and abdominal ultrasonography and died 3.5 months after diagnosis. The cat had 14 kittens with three queens, including his female sibling, with an age range of 3 months to 8 years. Genetic testing to confirm the genetic transmission of AD-PKD which detects the mutated PKD1 gene was performed. Abdominal ultrasonography confirmed the presence of renal cysts. Nineteen cats were screened in the present study (13 males and 6 females), with an age range of 3 months to 8 years. The results of renal ultrasonography agreed with the genetic test results in the 19 cats in which both tests were performed and 8 cats were diagnosed as ADPKD based on these tests. AD-PKD has not been investigated in cats in South Korea. Moreover, this is the first report of AD-PKD in a family unit of Scottish Fold cats.
Keywords
Autosomal dominant polycystic kidney disease; feline; PCR/RFLP; Scottish Fold cats;
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1 Bonazzi M, Volta A, Gnudi G, Cozzi MC, Strillacci MG, Polli M, Longeri M, Manfredi S, Bertoni G. Comparison between ultrasound and genetic testing for the early diagnosis of polycystic kidney disease in Persian and Exotic Shorthair cats. J Feline Med Surg 2009; 11: 430-434.   DOI   ScienceOn
2 Domanjko-petric A, Cernec D, Cotman M. Polycystic kidney disease: a review and occurrence in Slovenia with comparison between ultrasound and genetic testing. J Feline Med Surg 2008; 10: 115-119.   DOI
3 Eaton KA, Biller DS, Dibartola SP, Radin MJ, Wellman ML. Autosomal dominant polycystic kidney disease in Persian and Persian-cross cats. Vet Pathol 1997; 34: 117-126.   DOI   ScienceOn
4 Helps C, Tasker S, Harley R. Correlation of the feline PKD1 genetic mutation with cases of PKD diagnosed by pathological examination. Exp Mol Pathol. 2007; 83: 264-268.   DOI   ScienceOn
5 Lyons LA, Biller DS, Erdman CA, Lipinski MJ, Young AE, Roe BA, Qin B, Granhn RA. Feline polycystic kidney disease mutation identified in PKD1. J Am Soc Nephrol 2004; 15: 2548-2555.   DOI   ScienceOn
6 Volta A, Manfredi S, Gnudi G, Gelati A, Bertoni G. Polycystic kidney disease in a Chartreux cat. J Feline Med Surg 2010; 12: 138-140.   DOI   ScienceOn
7 Barrs VR, Gunew M, Foster SF, Beatty JA, Malik R. Prevalence of autosomal dominant polycystic kidney disease in Persian cats and related-breeds in Sydney and Brisbane. Aust Vet J 2001; 79: 257-259.   DOI   ScienceOn
8 Barthez PY, Rivier P, Begon D. Prevalence of polycystic kidney disease in Persian and Persian related cats in France. J Feline Med Surg 2003; 5: 345-347.   DOI   ScienceOn
9 Beck C, Lavelle RB. Feline polycystic kidney disease in Persian and other cats: a prospective study using ultrasonography. Aust Vet J 2001; 79: 181-184.   DOI   ScienceOn
10 Biller DS, Dibartola SP, Eaton KA, Pflueger S, Wellman ML, Radin MJ. Inheritance of polycystic kidney disease in Persian cats. J Hered 1996; 87: 1-5.   DOI   ScienceOn
11 Cannon MJ, Mackay AD, Barr FJ, Rudorf H, Bradley KJ, Gruffydd-jones TJ. Prevalence of polycystic kidney disease in Persian cats in the United Kingdom. Vet Rec 2001; 149: 409-411.   DOI   ScienceOn