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Diagnosis and Management of Feline Hyperthyroidism Complicated with Chronic Kidney Disease  

Kang, Min-Hee (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Deseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Park, Hee-Myung (BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Deseases and Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Publication Information
Journal of Veterinary Clinics / v.27, no.6, 2010 , pp. 723-725 More about this Journal
Abstract
A 14-year-old spayed, mixed breed, female cat was admitted for evaluation of a polyphagia, hyperactivity and chronic weight loss. Physical examination revealed a tachycardia and mild elevated systemic blood pressure. This cat had azotemia and mild increased total thyroxin (TT4) and free thyroxin concentration. However triiodothyronine (T3) level was normal, the T3 suppression test for definite diagnosis were made. No changes of TT4 serum concentration before and after the exogenous T3 administration in this cat showed hyperthyroidism. This cat was diagnosed as mild hyperthyroidism concurrent with chronic kidney disease (CKD) and antithyroid drug, methimazole, was used for medical management. This is first case report describing clinical and laboratory characteristic features of feline hyperthyroidism complicated with CKD and its clinical outcome using medical management in our country.
Keywords
Cat; Chronic kidney disease; Hyperthyroidism; Methimazole;
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1 Williams TL, Peak KJ, Brodbelt D, Elliott J, Syme HM. Survival and the development of azotemia after treatment of hyperthyroid cats. J Vet Intern Med 2010; 24: 863-869.   DOI   ScienceOn
2 May SN, Langston CE. Managing chronic renal failure. Compend Contin Educ Pract Vet 2006; 853-863.
3 Peterson ME, Graves TK, Gamble DA. Triiodothyronine (T3) suppression test - an aid in the diagnosis of mild hyperthyroidism in cats. J Vet Intern Med 1990; 4: 233-238.   DOI
4 Peterson ME, Kintzer PP, Hurvitz AI. Methimazole treatment of 262 cats with hyperthyroidism. J Vet Intern Med 1988; 2: 150-157.   DOI
5 Riensche MR, Graves TK, Schaeffer DJ. An investigation of predictors of renal insufficiency following treatment of hyperthyroidism in cats. J Feline Med Surg 2008; 10: 160-166.   DOI   ScienceOn
6 Shirota T, Shinoda T, Yamada T, Aizawa T. Alteration of renal function in hyperthyroidism: increased tubular secretion of creatinine and decreased distal tubule delivery of chloride. Metabolism 1992; 41: 402-405.   DOI   ScienceOn
7 Trepanier LA. Medical management of hyperthyroidism. Clinc Tech Small Anim Pract 2006; 21: 22-28.   DOI   ScienceOn
8 Wakeling J, Moore K, Elliott J, Syme H. Diagnosis of hyperthyroidism in cats with mild chronic kidney disease. J Small Anim Pract 2008; 49: 287-294.   DOI
9 Becker TJ, Graves TK, Kruger JM, Braselton WE, Nachreiner RF. Effects of methimazole on renal function in cats with hyperthyroidism. J Am Anim Hosp Assoc 2000; 36: 215-223.
10 Adams WH, Daniel GB, Legendre AM. Investigation of the effects of hyperthyroidism on renal function in the cat. Can J Vet Res 1997; 61: 53-56.
11 Feldman EC, Nelson RW. Feline hyperthyroidism. In: Canine and Feline Endocrinology and Reproduction 2nd ed. Philadelphia: WB Saunders, 1996; 118-165.
12 Graves TK, Olivier NB, Nachreiner RF, Kruger JM, Walshaw R, Stickle RL. Changes in renal function associated with treatment of hyperthyroidism in cats. Am J Vet Res 1994; 55: 1745-1749.
13 Hoffmann G, Marks SL, Taboada J, Hosgood GL, Wolfsheimer KJ. Transdermal methimazole treatment in cats with hyperthyroidism. J Feline Med Surg 2003; 5: 77-82.   DOI   ScienceOn
14 Maddison J, Syme H. Chronic kidney disease in dogs and cats: pathophysiology and diagnosis. Ir Vet J 2009; 63: 44-50.