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Effects of Medetomidine and Tramadol Administration on the Minimum Alveolar Concentration of Isoflurane in Dogs  

Kim, Kyung-Mi (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
Cheong, Jong-Tae (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
Park, Hyun-Jeong (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
Publication Information
Journal of Veterinary Clinics / v.27, no.6, 2010 , pp. 668-673 More about this Journal
Abstract
This study was to evaluate the effects of tramadol and medetomidine administration on minimum alveolar concentration (MAC) of isoflurane in dogs. MAC of isoflurane was determined in four occasions; 1 ml saline (Control), $2{\mu}g$/kg medetomidine (M2), 4 mg/kg tramadol (T4), $2{\mu}g$/kg medetomidine-4 mg/kg tramadol combination (M2T4). Heart rate, blood pressure, respiratory rate, end-tidal carbon dioxide concentration, saturation of hemoglobin with oxygen and body temperature were recorded. After administration of M2 ($0.81{\times}0.18%$), T4 ($0.81{\times}0.14%$) and M2T4 ($0.62{\times}0.12%$), less isoflurane was required than the control value ($1.13{\times}0.19%$). Significantly lower heart rate than the control value was detected after treatment of M2, T4, and M2T4. When only M2T4 was administered, blood pressure was significantly higher than the control value. In conclusion, administrations of tramadol, medetomidine and medetomidine-tramadol combination decreased the MAC of isoflurane in dogs. Especially, medetomidine-tramadol combinations could be useful as a premedication because of the anesthetic sparing effect and moderate changes in cardiovascular system.
Keywords
medetomidine; tramadol; minimum alveolar concentration (MAC); isoflurane; dog;
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