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Residue Depletion of the Sulfaquinoxaline and Trimethoprim Combination in Broilers  

Lim, Jong-Hwan (B&C Biopharm)
Hwang, Youn-Hwan (Research Institute of Veterinary Science, Chungnam National University)
Kim, Myoung-Seok (Research Institute of Veterinary Science, Chungnam National University)
Song, In-Bae (Research Institute of Veterinary Science, Chungnam National University)
Park, Byung-Kwon (JEONJINBIO)
Yun, Hyo-In (Research Institute of Veterinary Science, Chungnam National University)
Publication Information
Journal of Veterinary Clinics / v.27, no.5, 2010 , pp. 565-568 More about this Journal
Abstract
Sulfaquinoxaline (SQX) and trimethoprim (TMP) are chemotherapeutics that are extensively used in various animal species for the treatment or prevention of coccidia and coccidia-like parasites. Little information about the depletion kinetics of these compounds in chickens exists in the literature. In this study, a new commercial liquid concentrate of SQX in combination with TMP (100 g/l of SQX and 33.4 g/l of TMP) was administered with drinking water at a dose of 0.75 ml/l or 1.5 ml/l. The edible tissue concentrations of the drugs were determined by the validated high-performance liquid chromatography/mass spectrometric method. Residue concentrations of SQX and TMP were lower than their maximum residual limits (MRLs) in all tissues from both dose groups at 5 days after the treatment. The optimal withdrawal time of SQX/TMP combination was suggested to be over 5 days after cessation of medication in broilers.
Keywords
sulfaquinoxalin; trimethoprim; broiler; residues;
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