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Effect of Epimedium Koreanum on the 2-Bromopropane Induced-Reproductive Damage  

Kim, Joo-Wan (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Kim, Hong-Tae (Busan Metropolitan City Institute of Health & Environment)
Lee, Sung-Dong (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Lim, Mee-Kyoung (Department of Food Science and Nutrition, College of Human Ecology, Kyungpook National University)
Ku, Sae-Kwang (Department of anatomy and histology, College of Oriental Medicine, Daegu Haany University)
Park, Hyun-Jeong (Department of Veterinary Radiology, College of Veterinary Medicine, Jeju National University)
Oh, Tae-Ho (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Lee, Keun-Woo (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Publication Information
Journal of Veterinary Clinics / v.27, no.5, 2010 , pp. 514-521 More about this Journal
Abstract
Epimedium koreanum nakai (EKN) has been used for treatment of reproductive disorders. In this study, we evaluated the effects of EKN water extract on the 2-bromopropane (2-BP) induced reproductive dysfunction. The daily sperm production (DSP), sperm counts and histological changes of reproductive organs were investigated after 4 weeks of EKN administration in 2-BP induced reproductive damaged rats. Although the weights of epididymis and seminal vesicle were increased dose-dependently, they were lower than control group. DSP of EKN-dosing groups were increased compared to control group. In EKN-dosing groups, the number of degenerative seminiferous tubules and the number of epididymal tubules showing epithelial cell vacuolation and decreased spermatozoa in the lumen were significantly (p < 0.01) decreased compared to control group dose-dependently. Significant (P < 0.05 or P < 0.01) increases of the number of sertoli cells, spermatogonia, patchytene spermatocytes, round spermatids and elongated spermatids were observed in EKN-dosing groups compared control group. Consequently, based on the results, EKN water extract could treat 2-BP induced reproductive damages dramatically.
Keywords
Epimedium koreanum; reproductive disorder; 2-bromopropane; rat;
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