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Safety Evaluation of Epimedium koreanum Water Extract in Sprague-Dawley Rats  

Kim, Joo-Wan (Department of Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Lim, Mee-Kyung (Department of Food Science and Nutrition, College of Human Ecology, Kyungpook National University)
Kim, Hong-Tae (Busan Metropolitan City Institute of health & Environment)
Ku, Sae-Kwang (Department of Anatomy and histology, College of Daegu Haany University)
Chang, Hey-Sook (Department of Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Oh, Tae-Ho (Department of Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Lee, Keun-woo (Department of Internal Medicine, College of Veterinary Medicine, Kyungpook National University)
Publication Information
Journal of Veterinary Clinics / v.27, no.2, 2010 , pp. 163-169 More about this Journal
Abstract
To evaluate of oral toxicity of Epimedium koreanum nakai (EKN) water extract, three doses of EKN water extract (10, 100 and 1000 mg/kg/day) were administered to healthy Sprague-Dawley rats for 4 weeks. The results showed that there are no abnormal signs during the experimental period. The weights of testis and epididymis were increased dose-dependently, but seminal vesicle was decreased compared with control group. In hematology and serum chemistry, changes were observed within the normal ranges. In histological finding, slight to moderated changes were found but those were commonly or rarely encountered in the normal rats. These results suggest that no observed adverse effect level (NOAEL) of the oral application of EKN was considered to be more than 1000 mg/kg in SD rats under the conditions employed in this study.
Keywords
Epimedium koreanum; Safety evaluation; Rat;
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