Browse > Article

Clinical Efficacy of Pimobendan on Dogs with Chronic Mitral Valvular Diseases  

Nam, So-Jeong (Section of Small Animal Internal Medicine, School of Veterinary Medicine, Kangwon National University)
Park, In-Chul (Section of Diagnostic Imaging, School of Veterinary Medicine, Kangwon National University)
Hyun, Chang-Baig (Section of Small Animal Internal Medicine, School of Veterinary Medicine, Kangwon National University)
Publication Information
Journal of Veterinary Clinics / v.26, no.1, 2009 , pp. 17-22 More about this Journal
Abstract
Pimobendan is a recently developed cardiac drug which is useful to control moderate to severe congestive heart failure (CHF) from chronic mitral valvular diseases (CMVI). Because of controversy related to the efficacy and safety of pimobendan in dogs, the optimal efficacy and safety of pimobendan was assessed in 20 dogs with CMVI in this study. Scores for quality of life, respiratory failure, circulatory failure and heart failure were evaluated along with radiographical and echocardiographical assessments for about 2 months period after the addition of pimobendan into the regular cardiac medications. This study proved clear evidence that pimobendan had beneficial therapeutic effects in dogs with advanced CMVI, without particular adverse effects. However, further studies are warranted to address the drug interaction with other cardiac therapeutics and to assess therapeutic effects in CHF from other type of heart diseases in dogs and other animals.
Keywords
pimobendan; heart failure; mitral valvular disease; CMVI; dog;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 Beardow AW, Buchanan JW. Chronic mitral valve disease in cavalier King Charles spaniels: 95 cases (1987–1991). J Am Vet Med Assoc 1993; 203: 1023–1029   PUBMED
2 Chu KM, Shieh SM, Hu OY. Pharmacokinetics and pharmacodynamics of enantiomers of pimobendan in patients with dilated cardiomyopathy and congestive heart failure after single and repeated oral dosing. Clin Pharmacol Ther 1995; 57: 610-621   DOI   ScienceOn
3 Haggstrom J, Hamlin RL, Hansson K. Heart rate variability in relation to severity of mitral regurgitation in Cavalier King Charles spaniels. J Small Anim Pract 1996; 37: 69–75   DOI   ScienceOn
4 Hyun C. Valvular disease. In: Textbook of Small Animal Cardiology, Seoul: Panmoon Publishing. 2005: 185–206
5 Justin D. Thomason, Tiffany K. Fallaw, Clay A. Calvert. Pimobendan: Understanding its cardiac effects in dogs with myocardial disease. Vet Med 2006: 660-667
6 Wess G. Assessment of left ventricular systolic and diastolic function in canine myxomatous mitral valve disease using myocardial tissue Doppler imaging. In: International canine valvular disease symposium, Stockholm, Sweden. 2008: 44-45
7 H$\ddot{a}$ggstr$\ddot{o}$m J, Boswood A, O'Grady M, J$\ddot{o}$ns O, Smith S, Swift S, Borgarelli M, Gavaghan B, Kresken JG, Patteson M, Ablad B, Bussadori CM, Glaus T, Kova evi A, Rapp M, Santilli RA, Tidholm A, Eriksson A, Belanger MC, Deinert M, Little CJ, Kvart C, French A, Rønn-Landbo M, Wess G, Eggertsdottir AV, 'Sullivan ML, Schneider M, Lombard CW, Dukes-McEwan J, Willis R, Louvet A, Difruscia R. Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring oyxomatous mitral valve disease: The QUEST study. J Vet Intern Med 2008; 22: 1124-1135   DOI   ScienceOn
8 Lombard CW, Jons O, Bussadoril CM. Clinical efficacy of pimobendan versus benazepril for the treatment of acquired atrioventricular valvular disease in dogs. J Am Anim Hosp Assoc 2006; 42: 249-261   PUBMED
9 Fuentes VL, Corcoran B, French A, et al. A double-blind, randomized, placebo-controlled study of pimobendan in dogs with dilated cardiomyopathy. J Vet Intern Med 2002; 16: 255-261   DOI   ScienceOn
10 Kleeman R, Lebobinnee G, Bruyere D. Clinical efficacy of the novel inodilator pimobendan in dogs suffering from congestive heart failure, in Proceedings. Br Small Anim Vet Congress 1998
11 Kittleson MD, Kienle RD. Myxomatous atrioventricular valvular degeneration. In: Small Animal Cardiovascular Medicine. St Louis: Mosby. 1998: 297–318
12 Hagemeijer F. Calcium sensitization with pimobendan: pharmacology, haemodynamic improvement, and sudden death in patients with chronic congestive heart failure. Eur Heart J 1993; 14: 551-566.   DOI   PUBMED   ScienceOn
13 Moon HS, Choi E, Hyun C. The cardiac sodium-calcium exchanger gene (NCX-1) is a potential canine cardiac biomarker of chronic mitral valvular insufficiency. J Vet Intern Med 2008; 22: 1360-1365   DOI   ScienceOn
14 Hyun C. Mitral valve prolapse in Cavalier King Charles spaniel: a review and case study. Vet Sci 2005; 6: 67-73   PUBMED
15 Serres F, Chetboul V, Tissier R, Poujol L, Gouni V, Carlos Sampedrano C, Pouchelon JL, 'Comparison of 3 ultrasound methods for quantifying left ventricular systolic function: correlation with disease severity and prognostic value in dogs with mitral valve disease', J Vet Intern Med. 2008; 22: 566-577   DOI   ScienceOn
16 Smith PJ, French AT, Van Israel N. Efficacy and safety of pimobendan in canine heart failure caused by myxomatous mitral valve disease. J Small Anim Pract 2005; 46: 121-130   DOI   ScienceOn
17 Fuentes VL. Use of pimobendan in the management of heart failure. Vet Clin North Am Small Anim Pract 2004; 34: 1145-1155   DOI   ScienceOn
18 Pouchelon JL, Jamet N, Gouni V, Tissier R, Serres F, Carlos Sampedrano C, Castaignet M, Lefebvre HP, Chetboul V. Effect of benazepril on survival and cardiac events in dogs with asymptomatic mitral valve disease: a retrospective study of 141 cases. J Vet Intern Med. 2008; 22: 905-914   DOI   ScienceOn
19 Rosenthal SL, Ferguson MJ, Lefbom BK. Association of pimobendan with ventricular arrhythmias in dogs with congestive heart failure, in Proceedings. Am Coll Vet Intern Med 2006; 110-115
20 Haggstrom J, Kvart C, Pedersen HD. Aquired valvular heart disease. In: Textbook of Veterinary Internal Medicine, 6 th ed. St Louis: Elsevier. 2005: 1022–1039
21 Lefbon BK. Sildenafil and novel cardiovascular therapies, in Proceedings. Am Coll Vet Intern Med 2005; 75-80.
22 Bonagura JD, Herring DS. Echocardiography; Acquired heart disease. Vet Clin North Am Small Anim Pract. 1985; 15: 1209-1224   PUBMED