Browse > Article

Topical Application of 0.1% Tacrolimus Ointment for Treatment of Sinus Refractory Pododermatitis Secondary to Atopy in a Dog  

Kim, Ha-Jung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Yoo, Jong-Hyun (BK21 program of Integrative network systems for veterinarians in basic science, industrial animals and preventive medicines, Konkuk University)
Park, Chul (Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California)
Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Publication Information
Journal of Veterinary Clinics / v.25, no.3, 2008 , pp. 202-206 More about this Journal
Abstract
An 8-year-old, castrated male Shih-tzu was referred due to relapsing pododermatitis and generalized pruritus. On physical examination, right forepaw showed swelling and serosanguinous exudates from sinus tract on dorsal paw. There were no remarkable findings on complete blood count (CBC), serum chemistry, and radiologic examination. On cytological examination of exudates from sinus tract, phagocyted bacteria and numerous degenerative neutrophils were noted. Results of deep skin scraping and plucking hair examination were unremarkable. Skin biopsy was performed and ruled out other skin diseases. Histopathology showed epidermal hyperplasia and diffuse mononuclear cell inflammation in dermal layer. Moreover, pyogranulomatous inflammation was demonstrated in subcutaneous layer. This case was clinically diagnosed as pododermatitis secondary to atopic dermatitis (AD). Clinical signs of pododermatitis were gradually improved following topical application of tacrolimus 0.1% ointment. This case report describes that tacrolimus ointment can be applicable for the treatment of refractory pododermatitis.
Keywords
dog; pododermatitis; tacrolimus;
Citations & Related Records

Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 Rosser EJ Jr. German shepherd dog pyoderma: a prospective study of 12 dogs. J Am Anim Hosp Assoc 1997; 33: 355-363   DOI
2 Anderson RK. Canine pododermatitis. Compend Cont Educat Pract Vet 1980; 11: 361-371
3 Bensignor E, Olivry T. Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded randomized controlled trial. Vet Dermatol 2005; 16: 52-60   DOI   ScienceOn
4 Marsella R, Nicklin CF. Investigation on the use of 0.3% tacrolimus lotion for canine atopic dermatitis: a pilot study. Vet Dermatol 2002; 13: 203-210   DOI   ScienceOn
5 Ellis C, Luger T, Abeck D, Allen R, Graham-Brown RA, De Prost Y, Eichenfield LF, Ferrandiz C, Giannetti A, Hanifin J, Koo JY, Leung D, Lynde C, Ring J, Ruiz-Maldonado R, Saurat JH. International Consensus Conference on Atopic dermatitis II (ICCAD II): clinical update and current treatment strategies. Br J Dermatol 2003; 148: S3-S10   DOI
6 Breathnach RM, Fanning S, Mulcahy G, Bassett HF, Jones BR. A study of dendritic cell and MHC class expression in dogs with immunomodulatory-responsive lymphocytic-plasmacytic pododermatitis. Vet J 2007 (In Press)
7 van den Berg AP, van Son WJ, Haagsma EB, The TH, Slooff MJ, de Leij LM. Prediction of the inhibition of IL-2 production by calcineurin inhibitors. Transplantation Proceedings 2001; 33: 1076-1077   DOI   ScienceOn
8 cott DW, Miller Jr. WH, Griffin CE. Bacterial skin disease. In: Small Animal Dermatology, 6th ed. Philadelphia: W.B. Saunders Company. 2001: 274-335
9 Muller GH. Skin diseases of the Chinese Shar-Pei. Vet Clin North Am Small Anim Pract 1990; 20: 1655-1670   DOI
10 Trautmann A, Akdis M, Schmid-Grendelmeier P, Disch R, Brocker EB, Blaser K, Akdis CA. Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis. J Allergy Clin Immunol 2001; 107: 345-352   DOI   ScienceOn
11 Sakuma S, Higashi Y, Sato N, Sasakawa T, Sengoku T, Ohkubo Y, Amaya T, Goto T. Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system (Comparison with steroids). Int Immunopharmacol 2001; 1: 1219-1226   DOI   ScienceOn
12 Yetman RJ, Parks D. Diagnosis and management of atopic dermatitis. J Pediatr Healthc 2002; 16: 143-145   DOI
13 Gupta AK, Adamiak A, Chow M. Tacrolimus: a review of its use for the management of dermatoses. J Eur Acad Dermatol Venereol 2002; 16: 100-114   DOI   ScienceOn
14 Marsella R, Nicklin CF, Saglio S, Lopez J. Investigation on the clinical efficacy and safety of 0.1% tacrolimus ointment (Protopic(R)) in canine atopic dermatitis: a randomized, doubleblinded, placebo-controlled, cross-over study. Vet Dermatol 2004; 15: 294-303   DOI   ScienceOn
15 Breathnach RM, Baker KP, Quinn PJ, Mcgeady TA, Aherne CM, Jones BR. Clinical, immunological and histopathological findings in a subpopulation of dogs with pododermatitis. Vet Dermatol 2005; 16: 364-372   DOI   ScienceOn
16 Soter NA, Fleischer AB Jr, Webster GF, Monroe E, Lawrence I. Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part II, safety. J Am Acad Dermatol 2001; 44: S39-S46   DOI   ScienceOn
17 Gewirtz AT, Sitaraman SV. Tacrolimus Fujisawa. Curr Opin in Investig Drugs 2002; 3: 1307-1311
18 Willemse A. Atopic skin disease: a review and a. reconsideration of diagnostic criteria. J Small Anim Prac 1986; 27: 771-778   DOI
19 Nghiem P, Pearson G, Langley RG. Tacrolimus and pimecrolimus: from clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis. J Am Acad Dermatol 2002; 46: 228-241   DOI   ScienceOn
20 Mason IS. Canine pyoderma. J Small Anim Pract 1991; 32: 381-386   DOI
21 White S. Pododermatitis. In: Locke PH, Harvey RG, Mason IS eds. Manual of Small Animal Dermatology. Gloucestershire: British Small Animal Veterinary Assocoation Publications. 1993: 146-156
22 Medleau L, Hnilica KA. Bacterial Pododermatitis. In: Small animal dermatology: A color of atlas and therapeutic guide, 2nd edn. Philadelphia: W.B. Saunders Company. 2006: 41