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Granulomatous Meningoencephalitis in an Old Dog ; magnetic resonance imaging and immunohistopathologic findings  

Jung, Dong-In (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Yoo, Jong-Hyun (BK21 Program of Inteegrative Network Systems for Veterinarians in Basic Science, Industrial Aninmals and Preventive Medicines, Konkuk University)
Kang, Byeong-Teck (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Park, Chul (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Gu, Su-Hyun (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Kim, Ju-Won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Jeon, Hyo-Won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Lee, So-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Woo, Eung-Je (College of Electronics and Information, Kyunghee University)
Sur, Jung-Hyang (Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University)
Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Publication Information
Journal of Veterinary Clinics / v.24, no.3, 2007 , pp. 406-409 More about this Journal
Abstract
A 12-year-old female mixed Chihuahua dog was referred because of acute blindness and progressive tetraparesis. Mutifocal lesions in the cerebrum were noted on brain magnetic resonance images and cerebrospinal fluid analysis showed monocytic pleocytosis. Based on these results, granulomatous meningoencephalitis (GME) was strongly suspected. Cerebral lesions were definitely diagnosed as GME based on histopathological findings and positive results of immunohistological stains of brain with T-cell marker (CD3). This report describes the clinical findings, diagnostic imaging characteristics, and immunohistopathologic features of GME in an old dog. In addition, this case demonstrates that clinical signs of GME were mediated by perivascular infiltration of T lymphocytes and identification of causes in T cell-mediated inflammation should be further studied.
Keywords
dog; granulomatous meningoencephalitis (GME); magnetic resonance imaging (MRI); immunohistopathology;
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