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Acute Fulminating Myasthenia Gravis in a Shih-tzu Dog  

Kang, Byeong-Teck (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Yoo, Jong-Hyun (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University)
Park, Hyo-Jin (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Jung, Dong-In (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Park, Chul (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Gu, Su-Hyun (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Jeon, Hyo-Won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Kim, Ju-Won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Kim, Ha-Jung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Lim, Chae-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Cho, Sue-Kyung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Lee, So-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Heo, Ra-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
Publication Information
Journal of Veterinary Clinics / v.23, no.4, 2006 , pp. 465-468 More about this Journal
Abstract
A 3-year-old, spayed female Shih-tzu dog was presented due to acute vomiting, diarrhea, and generalized weakness. The dog had generalized weakness, increased respiratory rate, and respiratory muscle effect. Neurologic examination revealed appendicular muscular weakness and decreased in tone of the anal sphincter. Megaesophagus was confirmed by radiographic examinations. Other than type 2 fiber atrophy, no specific abnormalities were identified in histopathologic examinations of muscle biopsies from the left pelvic limb. Serum acetylcholine receptor (AChR) antibody titer was increased (0.78 nmol/L reference range, less than 0.6 nmol/L), confirming a diagnosis of acute fulminating myasthenia gravis. The dog dramatically responded to pyridostigmine bromide and had marked improvement in muscle strength, megaesophagus, and respiratory function. The dog has been successfully managed for 7 months after initial treatment.
Keywords
acetylcholine receptor (AChR) antibody titer; acute fulminating myasthenia gravis; megaesophagus; type 2 fiber atrophy;
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Times Cited By KSCI : 2  (Citation Analysis)
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