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Effect of Treatment with Transdermal Ketoprofen on Adjuvant-Induced Arthritis  

Shim, Kyung-Mi (College of Veterinary Medicine and Biotechnogy Research Institute, Chonnam National University)
Kim, Se-Eun (College of Veterinary Medicine and Biotechnogy Research Institute, Chonnam National University)
Bae, Chun-Sik (College of Veterinary Medicine and Biotechnogy Research Institute, Chonnam National University)
Choi, Seok-Hwa (College of Veterinary Medicine, Chungbuk National University)
Kang, Seong-Soo (College of Veterinary Medicine and Biotechnogy Research Institute, Chonnam National University)
Publication Information
Journal of Veterinary Clinics / v.23, no.4, 2006 , pp. 400-404 More about this Journal
Abstract
This study demonstrates the anti-arthritic effect of topical application of ketoprofen gel containing N-methyl-2-pyrrolidone (NMP) in adjuvant arthritis therapy. Adjuvant arthritis was induced by a single injection of Freund's complete adjuvant (FCA). Mature female Sprague-Dawley rats were designated to 3 groups such as control group, K10 group (ketoprofen 10 mg/rat), and NK10 group (ketoprofen 10 mg/rat containing NMP). The anti-arthritic activity of ketoprofen containing NMP was tested not only as to its capability to suppress the inflammatory edema, but also bone damage (X-ray score and regional bone uptake) of the hind paw in arthritis-induced rats. These results showed a higher efficacy of ketoprofen containing NMP than ketoprofen treatment in the adjuvant-induced arthritis. Ketoprofen containing NMP has good intrinsic characteristics for formulation in an efficacious anti-inflammatory topical application.
Keywords
Adjuvant arthritis; Ketoprofen; N-methyl-2-pyrrolidone; rat;
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