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Primary Dilated Cardiomyopathy in a Miniature Pinscher Dog  

Kim, Jung-Hyun (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University)
Park, Chul (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University)
Ko, Ki-Jin (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University)
Kang, Byeong-Teck (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University)
Jung, Dong-In (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University)
Kim, Ju-Won (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University)
Kim, Ha-Jung (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University)
Lim, Chae-Young (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University)
Lee, So-Young (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University)
Cho, Sue-Kyung (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University)
Park, Hee-Myung (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University)
Publication Information
Journal of Veterinary Clinics / v.23, no.3, 2006 , pp. 349-354 More about this Journal
Abstract
A 9-month-old, female Miniature Pinscher(MP) dog weighing 1.97kg was presented because of periodic syncopal episode for 5 months. This case was diagnosed as primary dilated cardiomyopathy based on respiratory distress history, weak femoral pulse, generalized cardiomegaly, pulmonary edema, marked dilation of left atrium(LA) and left ventricle(LV), decreased wall thickness of LV and interventricular septum(IVS), increased EPSS in echocardiography, and young age of onset in the absence of other cardiovascular disorders. The patient was stabilized by application of diuretics(Furosemide, 2 mg/kg, SC, q 1 hr) and venodilator(Nitroglycerine patch, 0.5 mg/kg, q 12 hrs). Clinical signs were improved with medical management of positive inotropic vasodilator(Pimobendan, 0.2 mg/kg, PO, q 12 hrs) and angiotensin-converting enzyme(ACE) inhibitor(benazepril, 0.5 mg/kg, PO, q 12 hrs), potassium gluconate gel(2 mEq/dog, PO, q 12 hrs) and, L-carnitine(50 mg/kg, PO, q 12 hrs). The dog still maintains stable clinical status 10 months after the first visit. We report the rare case of DCM in small breed dog, which corresponds to the diagnosis and treatment of typical DCM in large breed dog.
Keywords
dilated cardiomyopathy; syncope; Miniature Pinscher; pulmonary edema;
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1 Borgarelli M, Santilli R.A, Chiavegato D, D'Agnolo G, Zanatta R, Mannelli A, Tarducci A. Prognostic Indicators for Dogs with Dilated Cardiomyopathy. J Vet Intern Med 2006; 20: 104-110   DOI
2 Broschk C, Distl O. Dilated cardiomyopathy in dogs: pathological, clinical, diagnosis and genetic aspects. Dtsch Tierarztl Wochenschr 2005; 112: 380-385
3 Calvert CA, Chapman WL, Total RL. Congestive cardiomyopathy in Doberman Pinscher dogs. J Am Vet Med Assoc 1982; 181: 598-602
4 Calvert CA, Hall G, Jacobs G, Pickus C. Clinical and pathologic findings in Doberman pinschers with occult cardiomyopathy that died suddenly or developed congestive heart failure 54 cases (1984-1991). J Am Vet Med Assoc 1997; 210: 505-511
5 Calvert CA, Jacobs GJ, Pickus CW. Bradycardia-associated episodic weakness, syncope, and aborted sudden death in cardiomyopathic Doberman Pinschers. J Vet Intern Med 1996; 10: 88-93   DOI
6 Calvert CA., Pickus CW, Jacobs G.J, brown J. Signalement, survival and prognostic factors in Doberman Pinschers with end-stage cardiomyopathy. J Vet Intern Med 1997; 11: 323-326   DOI   ScienceOn
7 Keene BW, Panciera DP, Atkins CE. Myocardial L-carnitine deficiency in a family of dogs with dilated cardiomyopathy. J Am Vet Med Assoc 1991; 198: 647-650
8 Kittelson MD, Keene B, Pion PD, Loyer CG. Results of the multicenter spaniel trial (MUST): taurine and carnitine responsive dilated cardiomyopathy in American Cocker Spaniels with decreased plasma taurine concentration. J Vet Intern Med 1997; 11: 204-211   DOI   ScienceOn
9 Limas CJ, Goldenberg IF, Limas C. Autoantibodies against beta-adrenoseptors in human idiopathic dilated cardiomyopathy. Cir Res 1989; 64: 97-103   DOI   ScienceOn
10 Michael R. O'Grady, and Lynne O'sullivan M. Dilated cardiomyopthy: an update. Vet Clin Small Anim 2004; 34: 1187-1207   DOI   ScienceOn
11 Sandusky GE, Cho DY. Congestive cardiomyopathy in a dog associated with pregnancy. Cornell Vet 1984; 74: 60-64
12 Schultheiss HP, Bolte HD. Immunological analysis of auto-antibodies against the adenine nucleotide trans locator in dilated cardiomyopathy. J Mol Cell Cardiol 1985; 17: 603-617   DOI   ScienceOn
13 Sisson DD, Thomas WP, Keene BW. Primary myocardial disease in the dog. In: Ettinger SJ, Felman EC, editors. Textbook of veterinary internal medicine 5th edition Philadelphia. WB Saunders 2000: 874-895
14 Tidholm A, Jonsson L. Dilated cardiomyopathy in the Newfoundland: a study of 37 cases (1983-1994). J Am Anim Hosp Assoc 1996; 32: 465-470
15 Freeman LM, Michel KE, Brown DJ, Kaplan PM, Stamoulis ME, Posenthal SL, Keene BW, Rush JE. Idiopathic dilated cardiomyopathy in dalmatians: nine cases (1990-1995). J Am Vet Med Assoc 1996; 209: 1592
16 Tidholm A, Haggstrom J, Borgarelli M, Tarducci A. Canine Idiopathic Dilated Cardiomyopathy. Part I: Aetiology, Clinical Characteristics, Epidemiology and Pathology. Vet J 2001; 162: 92-107   DOI   ScienceOn
17 Monnet E, Orton C, Salman M, et al. Idiopathic dilated cardiomyopathy in dogs: survival and prognostic indicators. J Vet Intern Med 1995; 9: 12-17   DOI   ScienceOn
18 Keene BW, Panciera DP, Atkins CE, Reqitz V, Schmidt MJ, Shug AL. Myocardial carnitine deficiency in a family of dog with dilated cardiomyopathy. J Am Vet Med Assoc. 1991; 198: 647-650
19 O'Grady MR, O'Sullivian ML. Dilataed cardiomyoopathy: an update. Vet Clin North Am Samll Anim Prac 2004; 34: 1187-1207   DOI   ScienceOn
20 Kittleson MD. Primary myocardial disease leading to chronic myocardial failure (dilated cardiomyopathy and realated diseases). In: Kittleson MD, Kienle RD, editors. Small animal cardiovascular medicine. St Louis Mosby; 1998: 319-346
21 Olson TM, Michels VV, Thibodeau SN, Tai YS, Keating MT. Actin mutations in dilaed cardiomyopathy, a heretable form of heart failure. Science 1998; 280: 750-752   DOI   ScienceOn
22 Dominique GJ, Josee and Jean PV. The royal canin Dog encyclopedia. Aniwa publishing: 67-68
23 Lazaros A. Nikolaidis, MD. Angiotensin-converting enzyme inhibitors improve coronary flow reserve in dilated cardiomyopathy by a bradykini-mediated, Nitric Oxide-Dependent Mechanism. Circulation 2002: 2785-2790
24 Borgarelli M, Tarducci A, Santilli RA, Priano L. Fattori prognostici ecocardiografici ed eco Doppler in cani conmiocardiopatia dilatativa. Atti S I S Vet 1998; 52: 233
25 Joanna Dukes-McEwan. Dilated Cardiomyopathy: European Experience. The 23rd Proceedings of American College of Veterinary Internal Medicine Forum 2005: 101-103
26 Staaden RV. Cardiomyopathy of English Cocker Spaniels. J Am Vet Med Assoc 1981; 178: 1289-1292
27 Keene BW. L-carnitine deficiency in canine dilated cardiomyopathy. In Kirk RW, Bonagura JD (Eds). Kirk's Current Veterinary Therapy XI WB Saunders Co Philadelphia 1992: 780
28 Sisson D, O'Grady MR, and Calvert CA. Myocardial disease of dogs. In: Fox PR., Sisson D, and Moise NS, (eds), Canine and Feline Cardilolgy 2nd edn. WB Saunders Philadelphia 1999: 581-619
29 Wynne J, Braunwald E. The cardiomyopathies and myocarditides. In: Braunwald E, Zipes DP, Libby P, editors. Heart disease: a textbook of cardiovascular medicine. 6th edition. Philadelphia. WB Saunders 2001: 1751-1806
30 O'Grady MR, Minors SL. Resting and dobutamine stress echocardiographic factors associated with the development of occult dilated cardiomyopathy in healthy Doberman pinscher dogs. J Vet Intern Med 1998; 12: 369-380   DOI   ScienceOn
31 Morales M, Ynaraja E, Montoya JA. Dilated cardiomyopathy in Presa Canario dogs: ECG findings. J Vet Med Assoc 2001; A 48: 577-580
32 Borgarelli M, Tarducci A, Tidholm A, Haggstrom J. Canine Idiopathic Dilated Cardiomyopathy. Part II: Pathophysiology and therapy. Vet J 2001; 162: 182-195   DOI   ScienceOn