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Trial of Mycophenolate Mofetil Treatment on Necrotizing Meningoencephalitis in a Yorkshire Terrier Dog  

Jeon, Hyo-Won (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Park, Chul (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Jung, Dong-In (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Kang, Byeong-Teck (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Kim, Ha-Jung (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Kim, Ju-Won (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Lim, Chae-Young (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Ko, Ki-Jin (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Lee, So-Young (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Cho, Sue-Kyung (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Gu, Su-Hyun (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Heo, Ra-Young (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Park, Hyo-Jin (Department of veterinary internal medicine, College of veterinary medicine, Konkuk University)
Publication Information
Journal of Veterinary Clinics / v.23, no.3, 2006 , pp. 344-348 More about this Journal
Abstract
A 5-year-old, male Yorkshire terrier dog was presented with progressive seizure and anorexia. Definitive diagnosis of necrotizing meningoencephalitis(NME) was made based on characteristic clinical features, brain lesion with MRI, and histopathologic examination. The dog was treated with prednisolone for 20 days, firstly. Prednisolone and mycophenolate mofetil(MMF) were then administered for 40 days following the initial therapy. However, the clinical signs were not improved and seizure frequency was increased. This patient survived around 2 months after diagnosis. This case report described the clinical findings, imaging characteristics and pathologic features of NME in a Yorkshire terrier with trial treatment using MMF.
Keywords
necrotizing meningoencephalitis; seizure; mycophenolate mofetil;
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