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Pharmacomkinetics of Roxithromycin after Intravenous Administration in Broilers  

Lim Jong-Hwan (B&C Biopharm)
Park Byung-Kwon (College of Veterinary Medicine, Chungnam National University)
Kim Myoung-Seok (College of Veterinary Medicine, Chungnam National University)
Hwang Youn-Hwan (College of Veterinary Medicine, Chungnam National University)
Yun Hyo-In (College of Veterinary Medicine, Chungnam National University)
Publication Information
Journal of Veterinary Clinics / v.23, no.2, 2006 , pp. 87-90 More about this Journal
Abstract
The aim of the present study was to investigate the disposition pharmacokinetics of roxithromycin in broilers. Roxithromycin was administered at a single dose of 20 mg/kg body weight by intravenous (i.v.) routes. Plasma concentrations of roxithromycin were determined by liquid chromatography/mass spectrometry. After a single i.v. dose plasma concentrations were best fitted to a two-compartment open model. The values of the pharmacokinetic parameters after i.v. administration were: elimination half-life = $5.83{\pm}1.79h$, mean residence time = $6.33{\pm}0.32h$, total body clearance = $0.55{\pm}0.15L/h/kg$, and volume of distribution at steady state = $3.47{\pm}0.84L/kg$. The pharmacokinetic interpretation of roxithromycin after i.v. administration revealed that the drug was well distributed throughout the body in broilers and slowly eliminated. More studies for the application of roxithromycin against poultry disease are needed to establish a suitable pharmaceutical formulation, propose optimum dosage regimens, investigate clinical efficacy and study the tolerability of repeated doses.
Keywords
Roxithromycin; pharmacokinetics; broilers;
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