Browse > Article

A Case of Acquired Myasthenia Gravis in German Shepherd Dog  

Lee Sang-Gwan (Joeun Animal Hospital)
Hoh Woo-Pil (Joeun Animal Hospital)
Kim Youn-Ju (College of Veterinary Medicine, Kyungpook National University)
Kim Tae-Wan (College of Veterinary Medicine, Kyungpook National University)
Yoo Jong-Hyun (College of Veterinary Medicine, Seoul National University)
Eom Ki-Dong (College of Veterinary Medicine, Kyungpook National University)
Oh Tae-Ho (College of Veterinary Medicine, Kyungpook National University)
Lee Keun-Woo (College of Veterinary Medicine, Kyungpook National University)
Publication Information
Journal of Veterinary Clinics / v.22, no.4, 2005 , pp. 392-395 More about this Journal
Abstract
A three-year old intact female German shepherd dog weighing 32kg was presented with the history of regurgitation and vomiting. Physical examination revealed a thin body condition, hoarse voice, hypersalivation, and pelvic limb weakness. In radiograph, meagaesophagus was identified. The neostigmine challenge test was positive. The titer of acetylcholine receptor (AChR) antibody was 1.58 nmol/L (reference range, <0.6nmol). Therefore, the dog was diagnosed to be suffering with chronic generalized form of acquired myasthenia gravis and followed by treatment with pyridostigmine bromide, 1mg/kg, q12 hrs. Treatment improved the pelvic limb weakness, however intermittent regurgitation and vomiting persisted. This resulted in aspiration pneumonia f3r which antibiotics were administered However, the dog was euthanized due to poor management and owner's request.
Keywords
Myasthenia gravis; acetycholine receptor antibody; pyridostigmine bromide; dog;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Shelton GD. Acquired myasthenia gravis: what we have learned from experimental and spontaneous animal models. Vet Immunol lmmunopathol 1999; 69: 239-249   DOI   ScienceOn
2 King LG. Medical management of the critical myasthenia patient. In: Proceedings of the 16th American College of Veterinary Internal Medicine Forum. San Diego 1998: 311-313
3 Shelton GD. Myasthenia gravis. Lessons from the past 10 years. J Small Anim Pract 1998; 39: 368-372   DOI   ScienceOn
4 Lindstrom J, Shelton D, Fujii Y. Myasthenia gravis. Adv Immunol 1988; 42: 233-284   DOI
5 Shelton GD, Schule A, Kass PH. Risk factors for acquired myasthenia gravis in dogs: 1,154 cases (1991-1995). J Am Vet Med Assoc 1997: 211: 1428-1431
6 Shelton GD. Myasthenia gravis and disorders of neuromuscular transmission. Vet Clin North Am Small Anim Pract 2002; 32: 189-206   DOI   ScienceOn
7 Inzana KD. Peripheral nerve disorder. In: Textbook of veterinary internal medicine 6th ed. St. Louis, Elsevier Sanunders Inc. 2005: 887-900
8 Osserman KE, Genkins G. Studies in myasthenia gravis. Review of a twenty-year experience in over 1200 patients. Mt Sianai J Med 1971; 38: 497-537