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Effect of Nandrolone Decanoate on Disuse Muscle Atrophy and Bone Beating in Dogs  

Yun Seong-jin (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Seoul National University)
Lim Ji-hey (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Seoul National University)
Rahman Md. Mizanur (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Seoul National University)
Byeon Ye-eun (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Seoul National University)
Kim Wan-hee (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Seoul National University)
Kweon Oh-kyeong (Laboratory of Veterinary Surgery, College of Veterinary Medicine, Seoul National University)
Publication Information
Journal of Veterinary Clinics / v.22, no.4, 2005 , pp. 336-341 More about this Journal
Abstract
Anabolic steroid compounds are widely used for the increase of muscle mass, density of bone and athletic ability. The present study conducted to evaluate the effects of nandrolone decanoate (ND), one of the anabolic steroid compounds, on disuse muscle atrophy and healing process of bone in dogs. Twenty physically healthy dogs of both sexes were used in this experiment and divided into three groups: group A (control), group B (low dose M-1.5 mg/kg) and group C (high dose ND-7.5 mg/kg). One-mm strip of full thickness bone was excised from the radius below the pronator teres muscle for the artificial fracture and then the fractured ends were fixed in apposition with bone plate leaving 1mm gap, and finally immobilized externally by Robert John's bandage for 4 weeks. ND was administered intramuscularly once a week far 8 weeks. Body weight, muscle mass change and fracture gap of the bone were evaluated immediately after surgery, and 2, 4, and 8 weeks after surgery. The rates of muscle mass change 8 weeks after surgery were $-2.75\pm0.16\%,\;1.68\pm0.11\%\;and\;1.74\pm0.48\%$ in groups A, B and C, respectively. The significant increase (p<0.05) of muscle mass increments were found in the treated groups. The fibrous connective tissue layer in the fracture gaps of the treated groups increased more than the control, especially in the group C at 4th week. More dense fibrous connective tissue were found in the treated groups at 8th week. Collectively, our results suggested that ND was an effective anabolic agent for the immobilized disuse muscle and bone healing.
Keywords
nandrolone decanoate; muscle; atrophy; dog;
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