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Adjuvant Glucocorticoids Therapy in Canine Mast Cell Tumor  

Kim Myung-jin (College of Veterinary Medicine, Chungnam National University)
Lee Jae-il (College of Veterinary Medicine, Chungnam National University)
Kim Young-suk (College of Veterinary Medicine, Chungnam National University)
Son Hwa-young (College of Veterinary Medicine, Chungnam National University)
Jun Moo-hyung (College of Veterinary Medicine, Chungnam National University)
Park Chang-sik (Division of Animal Science & Resources, Research Center for Transgenic Cloned Pigs, Chungnam National University)
Kim Myung-cheol (College of Veterinary Medicine, Chungnam National University)
Publication Information
Journal of Veterinary Clinics / v.22, no.3, 2005 , pp. 264-267 More about this Journal
Abstract
A 12-year-old, 8.0 kg, spayed female, mixed-breed dog was presented to the Veterinary Medical Teaching Hospital of Chungnam National University (VMTH, CNU). That case has been growing up mass in her left upper hindlimb about for 2 years and has showed vomiting and anorexia for 3 days. The patient was diagnosed with mast cell tumor on the basis of fine-needle aspiration (FNA) cytology techniques. According to World Health Organization clinical staging system for diagnosing mast cell tumors, it was classified into stage IIIa. The patient was treated by adjuvant corticosteroid therapy, but complete surgical excision was not achieved by owner's request. In the early stage of therapy, the size of the mass was gradually reduced with only adjuvant glucocorticoid therapy, so the patient's general condition was maintained well. But after 53 days later, the treatmant was not effective anymore and mass size was increased. Two months later, she was euthanized because of intermittent vomiting and severe respiratory distress. Splenic mass, duodenal ulceration, liver mass and infiltrated mast cell tumor in upper hindlimb muscle region were found in necropsy examination.
Keywords
mast cell tumor; corticosteroid therapy; dog;
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1 Lisa EM, Laura DG, Brad D, David SB. Spinal Mast Cell Tumorin a Dog. J Am Anim Hosp Assoc 2002; 38, 67-70
2 Renee AS, GNeal GM, Amiya KP, Karri AM. A prospective Study of Radiation Therapy for the treatment of grade 2 mast cell tumorsin 32 dogs. J Vet Intern Med 1996; 10, 376-378   DOI   ScienceOn
3 Jane MT, Barbara EK, Lisa MM, Alain T. Prognostic factor for radiation treatment of mast cell tumor in 85 dogs, J Am Vet Med Assoc 1988; 193, 936-940
4 Michels GM, Knapp DW, DeNicola DB. Prognosis following surgical excision of canine cutaneous mast cell tumors with histopathologically tumor-free versus non-tumor-free margins. J Am Anim Hosp Assoc 2002; 38, 458-466
5 Heather MM, Carolyn JH, Kathleen P, Jeff WT, Michael SB. Cutaneous Mast Cell Tumors in Cats: 32 Cases (1991-1994). J Am Anim Hosp Assoc 1998; 34, 281-284
6 David RD, Kenneth MW, John EJ, Ian DR, Peter JI. Vinblastine and Prednisolone as Adjunctive Therapy for Canine Cutaneous Mast Cell Tumors. J Am Anim Hosp Asooc 2004; 40, 124-130
7 Tomoko T, Tsuyosi K, Masayuki N, Manabu M, Satoru M, Ryohei N, Nobuo S. Inhibitory Effects of Glucocorticoids on Proliferation of Canine Mast Cell Tumor. J Vet Med Sci 1997; 59, 995-1001   DOI   ScienceOn
8 Chick W, Frances SS, Karin S. Recurrence Rates and Sites for Grade II Canine Cutaneous Mast Cell Tumors Following Complete Surgical Excision. J Am Anim Hosp Assoc 2002; 38, 71-73
9 Angela EF, Antony SM, Susan ML, John MG, Amy EB. Radiotherapy of Incompletely Resected, Moderately Differentiated Mast Cell Tumors in the Dog: 37 Cases (1989-1993), J Am Anim Hosp Assoc 1997; 33, 320-324
10 David M, Harvey HI, Lois R, Donald RC. Clostridial peritonitis associated with a mast cell tumor in a dog, J Am Vet Med Assoc 1986; 188, 188-190
11 Simoes JP, Schoning P, Butine M. Prognosis of Canine Mast Cell Tumors: A Comparison of Three Methods. Vet Pathol 1994; 31, 637-647   DOI   ScienceOn
12 Laura DK, David MV, William CK, Gregory KO, Lynn MY. Frequency of argyrophilic nucleolar organizer regions in fine-needle aspirates and biopsy specimens from mast cell tumors in dogs, J Am Vet Med Assoc 1996; 209, 1418-1420
13 Tamotsu I, Naohiro T, Par G, Eckard H, Akihiro O, Gary RF, Gary LJ, Erwin WG. Mast cell tumor necrosis factor a production is regulated by MEK kinases. Proc Natl Acad Sci 1997; 94, 6358-6363
14 Ronald LG, Giovanni DG, Caroline BS, Begonia P, Ronald M, David FM, Mari T. Mast Cell tumor destruction by deionized water. Am J Vet Res 1990; 51, 1116-1120
15 Howard DM, Daniel DL, Sylvia LL, Elliott RJ. Gastric mast cell tumor in a cougar, J Am Vet Med Assoc 1985; 187, 1258-1260