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Efficacy of itraconazole in 18 cases of Malassezia dermatitis in dogs  

Jeong A-young (Department of Veterinary Internal Medicine & Dermatology, College of Veterinary Medicine, Kyungpook National University)
Hoh Woo-phil (Department of Veterinary Internal Medicine & Dermatology, College of Veterinary Medicine, Kyungpook National University)
Jeong Hyo-hoon (Department of Veterinary Internal Medicine & Dermatology, College of Veterinary Medicine, Kyungpook National University)
Eom Ki-dong (Department of Veterinary Radiology, College of Veterinary Medicine, Kyungpook National University)
Lee Keun-woo (Department of Veterinary Internal Medicine & Dermatology, College of Veterinary Medicine, Kyungpook National University)
Oh Tae-ho (Department of Veterinary Internal Medicine & Dermatology, College of Veterinary Medicine, Kyungpook National University)
Publication Information
Journal of Veterinary Clinics / v.22, no.2, 2005 , pp. 90-93 More about this Journal
Abstract
Itraconazole was found to be an effective antifungal for the treatment of canine Malassezia dermatitis (MD). MD was diagnosed in 18 dogs, which were treated with itraconazole administered orally at 5 mg/kg of body weight, q12hrs, for 21 to 30 days. High prevalence breeds of MD were Maltese $(22\%)$, Cocker Spaniel $(17\%)$, Pekingese $(11\%)$, and Vizsla $(11\%)$. The dermatological signs of Malassezia dermatitis were crust $(31\%)$, alopecia $(25\%)$, hyperpigmentation $(25\%)$, scales$(19\%)$, erythema $(13\%)$, lichenification $(11\%)$, pustule $(11\%)$, ear swelling$(11\%)$, papules $(5\%)$, and offensive odor $(5\%)$. Commonly affected areas were ear canal $(41\%)$, axillae $(18\%)$, groin $(15\%)$, perianal $(12\%)$, ventral aspect of the neck $(9\%)$, interdigital spaces$(1\%)$, and muzzle $(1\%)$. Sixty seven percent of dogs with MD had cocci. Clinical responses of itraconazole were seen good, moderate, no responses of itraconazole, in $89\%,\;0\%,\;and\;11\%$, respectively, according to the owner's satisfaction to follow up call. Recurrence was detected on five good responsive dogs and adverse effects of the treatment were detected in only one dog. On the basis of this clinical study, itraconazole is a good choice in the treatment of canine Malassezia dermatitis. Efficacy, frequency of administration and veterinary approval are the major advantages.
Keywords
Malassezia dermatitis; itraconazole; dog;
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