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Effect of 1,3-Benzopyrone on Chemotactic Activity of Peripheral Blood Leukocytes in the Dog  

Kim Jee-hyun (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, and Research Institute of Veterinary Medicine, Chungbuk National University)
Kang Ji-houn (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, and Research Institute of Veterinary Medicine, Chungbuk National University)
Yang Mhan-pyo (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, and Research Institute of Veterinary Medicine, Chungbuk National University)
Publication Information
Journal of Veterinary Clinics / v.22, no.2, 2005 , pp. 84-89 More about this Journal
Abstract
This study was undertaken to examine whether 1,2-benzopyrone affects on chemotactic activity of canine peripheral blood leukocytes. A modified Boyden chamber method was sed on chemotaxis evaluation. The direct treatments of 1,2-benzopyrone showed no ffects on the chemotaxis of peripheral blood mononuclear cells (PBMCs) and olymorphonuclear cells (PMNs). But chemotaxis of PMN was remarkably enhanced by ulture supernatant from PBMC but not PMN treated with 1,2-benzopyrone. Similarly, it as also increased by recombinant (r) interleukin (lL)­8. This chemotactic activity of MN was inhibited by addition of anti-rIL-8 polyclonal antibody. The chemotaxis of PBMC was not enhanced by culture supernatant from either PBMC or PMN treated with 1,2-benzopyrone. Therefore, these results suggested that the chemotactic activity of PMN ay be mainly mediated by IL-8-like factor(s) produced from PBMC treated with ,2-benzopyrone.
Keywords
dog; 1,2-benzopyrone; chemotactic activity; leukocytes;
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