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Effects of the Administration of Human Menopausal Gonadotropin on the Pregnancy in Rats  

김영홍 (경북대학교 수의과대학)
이근우 (경북대학교 수의과대)
남현욱 (경북대학교 수의과대)
손창호 (전남대학교 수의과대학)
Publication Information
Journal of Veterinary Clinics / v.21, no.2, 2004 , pp. 109-114 More about this Journal
Abstract
The effect of Human Menopausal Gonadotropin(hMG) on the implantation, pregnancy, and the concentration of plasma progesterone were studied in pregnant rats. HMG 75 or 150 IU were administered once on day 1, 2, 3, 4, 9, 12 or 14 of gestation, respectively. Rats were autopsied on day 7 or 18. A single dose of hMG prevented implantation and terminated pregnancy in all of the rats by injecting on either day 1 or day 2 and this abortifacient action was effective 82-98% of pregnant rats on day 3 or 4 and 14-20% on day 9 or 12. Administration of hMG had no effect on termination of pregnancy on day 14. Plasma progesterone concentration by injecting hMG on day 1, 2, 3 or 4 were very decreased.
Keywords
hMG; hCG; progesterone; implantation; termination of pregnancy;
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